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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/20282
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dc.contributor.authorOliveira, F. S.-
dc.contributor.authorSantos, Márcio Roberto Viana dos-
dc.contributor.authorAntoniolli, Ângelo Roberto-
dc.contributor.authorMarchioro, Murilo-
dc.date.accessioned2024-10-15T15:06:01Z-
dc.date.available2024-10-15T15:06:01Z-
dc.date.issued2001-
dc.identifier.citationOLIVEIRA, F. S. et al. Differential effects of lead and zinc on inhibitory avoidance learning in mice. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 1, p. 117-120, jan. 2001. Disponível em: https://www.scielo.br/j/bjmbr/a/dNhKDzsnyBCBdpDXfZdWHjh/?format=pdf&lang=en. Acesso em: 15 out. 2024.pt_BR
dc.identifier.issn0100-879X-
dc.identifier.issn1414-431X-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/20282-
dc.languageengpt_BR
dc.publisherAssociação Brasileira de Divulgação Científicapt_BR
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchpt_BR
dc.subjectLeadeng
dc.subjectZinceng
dc.subjectInhibitory avoidanceeng
dc.subjectMemoryeng
dc.subjectChumbopor
dc.subjectZincopor
dc.subjectMemóriapor
dc.titleDifferential effects of lead and zinc on inhibitory avoidance learning in micept_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoWe studied the effects of chronic intoxication with the heavy metals lead (Pb2+) and zinc (Zn2+) on memory formation in mice. Animals were intoxicated through drinking water during the pre- and postnatal periods and then tested in the step-through inhibitory avoidance memory task. Chronic postnatal intoxication with Pb2+ did not change the step-through latency values recorded during the 4 weeks of the test (ANOVA, P>0.05). In contrast, mice intoxicated during the prenatal period showed significantly reduced latency values when compared to the control group (day 1: q = 4.62, P<0.05; day 7: q = 4.42, P<0.05; day 14: q = 5.65, P<0.05; day 21: q = 3.96, P<0.05, and day 28: q = 6.09, P<0.05). Although chronic postnatal intoxication with Zn2+ did not alter a memory retention test performed 24 h after training, we noticed a gradual decrease in latency at subsequent 4-week intervals (F = 3.07, P<0.05), an effect that was not observed in the control or in the Pb2+-treated groups. These results suggest an impairment of memory formation by Pb2+ when the animals are exposed during the critical period of neurogenesis, while Zn2+ appears to facilitate learning extinction.pt_BR
dc.description.localRibeirão Pretopt_BR
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