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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/20472
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dc.contributor.authorMatos, Humberto Reis-
dc.contributor.authorMarques, Sabrina de Almeida-
dc.contributor.authorGomes, Osmar Francisco-
dc.contributor.authorSilva, Alexandre Alves da-
dc.contributor.authorHeimann, Joel Claudio-
dc.contributor.authorDi Mascio, Paolo-
dc.contributor.authorMedeiros, Marisa Helena Gennari de-
dc.date.accessioned2024-11-19T16:13:02Z-
dc.date.available2024-11-19T16:13:02Z-
dc.date.issued2006-
dc.identifier.citationMATOS, H. R. et al. Lycopene and ß-carotene protect in vivo iron-induced oxidative stress damage in rat prostate. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 39, n. 2, p. 203-210, fev. 2006. Disponível em: https://www.scielo.br/j/bjmbr/a/BmxwSZZKKww44krKsdJLjKH/?format=pdf&lang=en. Acesso em: 19 nov. 2024.pt_BR
dc.identifier.issn0100-879X-
dc.identifier.issn1414-431X-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/20472-
dc.languageengpt_BR
dc.publisherAssociação Brasileira de Divulgação Científicapt_BR
dc.relation.ispartofBrazilian Journal of Medical and Biological Researchpt_BR
dc.subjectLycopeneeng
dc.subjectß-caroteneeng
dc.subjectDNA damageeng
dc.subject8-oxo-7,8-dihydro-2'-deoxyguanosineeng
dc.subjectFerric nitrilotriacetateeng
dc.subjectProstate cancereng
dc.subjectCâncer de próstatapor
dc.subjectLicopenopor
dc.subjectBetacarotenopor
dc.titleLycopene and ß-carotene protect in vivo iron-induced oxidative stress damage in rat prostatept_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoIt has been suggested that iron overload may be carcinogenic. In the present study, we evaluated the effect of plasma and prostate carotenoid concentration on oxidative DNA damage in 12-week-old Wistar rats treated with intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) (10 mg Fe/kg). Plasma ß-carotene and lycopene concentrations were measured as a function of time after ip injection of carotenoids (10 mg kg-1 day-1 ß-carotene or lycopene) in rats. The highest total plasma concentration was reached 3 and 6 h after ip injection of lycopene or ß-carotene, respectively. After 5 days of carotenoid treatment, lycopene and ß-carotene were present in the 0.10-0.51 nmol/g wet tissue range in the prostate. Using a sensitive method to detected 8-oxo-7,8- dihydro-2'-deoxyguanosine (8-oxodGuo) by HPLC/EC, the level of 8-oxodGuo in rat prostate DNA was significantly higher (6.3 ± 0.6 residues/106 dGuo) 3 h after Fe-NTA injection compared with control rats (1.7 ± 0.3 residues/106 dGuo). Rats supplemented with lycopene or ß-carotene for 5 days prior to Fe-NTA treatment showed a reduction of about 70% in 8-oxodGuo levels to almost control levels. Compared with control rats, the prostate of Fe-NTA-treated animals showed a 78% increase in malondialdehyde accumulation. Lycopene or ßcarotene pre-treatment almost completely prevented lipid damage. Epidemiological studies have suggested a lower risk of prostate cancer in men reporting a higher consumption of tomato products. However, before associating this effect with tomato sauce constituents, more information is required. The results described here may contribute to the understanding of the protective effects of carotenoids against iron-induced oxidative stress.pt_BR
dc.description.localRibeirão Pretopt_BR
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