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Tipo de Documento:	Artigo
Título:	Increased sympathetic activity in normotensive offspring of malignant hypertensive parents compared to offspring of normotensive parents
Autor(es):	Lopes, Heno Ferreira Consolim-Colombo, Fernanda Marciano Barreto-Filho, José Augusto Soares Riccio, Grazia Maria Guerra Negrão, Carlos Eduardo Krieger, Eduardo Moacyr
Data do documento:	Out-2008
Resumo:	Malignant hypertension seems to be the consequence of very high blood pressure. Furthermore, an increase in sympathetic and renin-angiotensin system activity is considered to be the main mechanisms producing malignant hypertension. In the present study, 10 offspring of malignant hypertensive (OMH) parents (age 28 ± 5 years, 7 males, 3 females, 2 white and 8 non-white) and 10 offspring of normotensive (ONT) parents (age 28 ± 6 years, 2 males, 8 females, 3 white and 7 non-white) were evaluated. The OMH group had significantly higher (P < 0.05) casual blood pressure (125 ± 10/81 ± 5 mmHg) compared with ONT (99 ± 13/67 ± 5 mmHg). The increase in blood pressure was greater in OMH (Δ SBP = 17 ± 2 vs Δ SBP = 9 ± 1 mmHg in ONT) during cold pressor testing, but they had a lower increase in heart rate (Δ HR = 13 ± 2 vs Δ HR = 20 ± 3 bpm in ONT) during isometric exercise (handgrip test). Sympathetic activity, measured by microneurography, was significantly higher (P < 0.05) before exercise in OMH (17 ± 6 vs 11 ± 4 burst/min in ONT) and exhibited a greater increase (Δ = 18 ± 10 vs Δ = 8 ± 3 burst/min in ONT) during isometric exercise. This study showed increased sympathetic activity in OMH before exercise and a greater response during isometric exercise, suggesting an autonomic abnormality before exercise and a greater sympathetic response to physical stress in OMH compared to ONT.
Palavras-chave:	Malignant hypertension Offspring of malignant hypertensive parents Sympathetic activity Microneurography Microneurografia
ISSN:	0100-879X 1414-431X
Parte de :	Brazilian Journal of Medical and Biological Research
Idioma:	eng
Instituição/Editora:	Associação Brasileira de Divulgação Científica
Citação:	LOPES, H. F. et al. Increased sympathetic activity in normotensive offspring of malignant hypertensive parents compared to offspring of normotensive parents. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 41, n. 10, p. 849-853, out. 2008. Disponível em: https://www.scielo.br/j/bjmbr/a/ZMH9LyZ9TYhWqg9bbMThqsd/?format=pdf. Acesso em: 27 jan. 2025.
Licença:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
URI:	https://ri.ufs.br/jspui/handle/riufs/20884
Aparece nas coleções:	DME - Artigos de periódicos

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