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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/21123
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Campo DCValorIdioma
dc.contributor.authorSoares, Rosilene Calazans-
dc.contributor.authorOliveira, Márcio Campos-
dc.contributor.authorSouza, Lélia Batista de-
dc.contributor.authorCosta, Antônio de Lisboa Lopes-
dc.contributor.authorPinto, Leão Pereira-
dc.date.accessioned2025-02-13T11:32:35Z-
dc.date.available2025-02-13T11:32:35Z-
dc.date.issued2008-10-
dc.identifier.citationSOARES, R. C. et al. Detection of HPV DNA and immunohistochemical expression of cell cycle proteins in oral carcinoma in a population of brazilian patients. Journal of Applied Oral Science, Bauru, v. 16, n. 5, p. 340-344, set./out. 2008. Disponível em: https://www.scielo.br/j/jaos/a/DdJNSdWwGydBXQ3wn3rRkDd/?format=pdf. Acesso em: 13 fev. 2025.pt_BR
dc.identifier.issn1678-7757-
dc.identifier.issn1678-7765-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/21123-
dc.languageengpt_BR
dc.publisherFaculdade De Odontologia De Bauru - Universidade de São Paulopt_BR
dc.relation.ispartofJournal of Applied Oral Sciencept_BR
dc.subjectDNA probeseng
dc.subjectHPVeng
dc.subjectCarcinomaeng
dc.subjectSquamous cell cancereng
dc.subjectPolymerase chain reactioneng
dc.subjectHybridizationeng
dc.subjectCell cycleeng
dc.titleDetection of HPV DNA and immunohistochemical expression of cell cycle proteins in oral carcinoma in a population of brazilian patientspt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoThis study investigated the presence of human papillomavirus (HPV) DNA and viral types in 33 cases of oral squamous cells carcinoma (OSCC) and compared the immunohistochemical expression of the cell-cycle markers p21 and pRb between cases of the disease with and without HPV. DNA was extracted from paraffin-embedded tissue and amplified by PCR for the detection of HPV DNA. Viral typing was performed by dot blot hybridization. Immunohistochemistry was performed by the streptavidinbiotin technique. HPV DNA was detected in 11 (33.33%) of the 33 cases. The prevalent viral type was HPV 18 (81.81%). A significant association was observed between the presence of HPV and immunohistochemical expression of pRb, but not between p21 expression and the presence of the virus. The low frequency of detection of HPV DNA in OSCC suggests a possible participation of the virus in the development and progression of only a subgroup of these tumors.pt_BR
dc.description.localBaurupt_BR
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