1. Repositório Institucional da Universidade Federal de Sergipe - RI/UFS
  2. PRODUÇÃO CIENTÍFICA
  3. DFS - Departamento de Fisiologia
  4. DFS - Artigos de periódicos
Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/23319
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dc.contributor.authorSousa, Damião Pergentino de-
dc.contributor.authorNobrega, Franklin Ferreira de Farias-
dc.contributor.authorSantos, Camila Carolina de Menezes-
dc.contributor.authorBenedito, Rubens Batista-
dc.contributor.authorVieira, Ygor Willian-
dc.contributor.authorUliana, Marciana Pierina-
dc.contributor.authorBrocksom, Timothy John-
dc.contributor.authorAlmeida, Reinaldo Nobrega de-
dc.date.accessioned2025-09-29T18:53:21Z-
dc.date.available2025-09-29T18:53:21Z-
dc.date.issued2012-08-
dc.identifier.citationSOUSA, D. P. et al. Antinociceptive activity of thymoquinone and its structural analogues: a structure-activity relationship study, Tropical journal of pharmaceutical research, Benin City, v. 11, n. 4, p. 605-610, ago. 2012. Disponível em: https://www.ajol.info/index.php/tjpr/article/view/80570. Acesso em: 29 set. 2025.pt_BR
dc.identifier.issn1596-9827-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/23319-
dc.languageengpt_BR
dc.publisherPharmacotheraphy Group - University of Beninpt_BR
dc.relation.ispartofTropical journal of pharmaceutical researchpt_BR
dc.subjectQuinonespor
dc.subjectAntinociceptive activitypor
dc.subjectAnalgesicpor
dc.subjectCentral nervous systempor
dc.subjectStructure-activity relationshippor
dc.subjectMedicinal plantpor
dc.titleAntinociceptive activity of thymoquinone and its structural analogues: a structure-activity relationship studypt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoPurpose: To investigate the structural features that influence the antinociceptive activity of thymoquinone and their structural analogues. Methods: The quinones were prepared by an oxidation procedure using molecular oxygen and catalysis with [CoII(salen)] from the respective phenols. The antinociceptive activity of para-benzoquinones (10 mg/kg, ip) was evaluated using formalin test in mice. Vehicle (5 % Tween 80) or morphine (10 mg/kg) were used as control group and standard drug, respectively. The amount of time spent licking the injected paw was considered as the nociceptive response. Results: Among the compounds tested, five para-benzoquinones showed antinociceptive activity. The 2-isopropyl-para-benzoquinone presented the highest potency in first and second phases and produced a near-maximal inhibition (p < 0.001) in the formalin test, similar to morphine (p < 0.001). Conclusion: Our experimental results show that by appropriate structural modification of parabenzoquinones it may be possible to develop novel analgesic drugs.pt_BR
dc.description.localBenin Citypt_BR
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