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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/23591
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dc.contributor.authorBarbosa, Flávio Freitas-
dc.contributor.authorSantos, José Ronaldo-
dc.contributor.authorMeurer, Ywlliane da Silva Rodrigues-
dc.contributor.authorMacêdo, Priscila Tavares-
dc.contributor.authorFerreira, Luane Maria Stamatto-
dc.contributor.authorFernandes, Isabella Maria de Oliveira Pontes-
dc.contributor.authorRibeiro, Alessandra Mussi-
dc.contributor.authorSilva, Regina Helena-
dc.date.accessioned2025-10-21T19:16:37Z-
dc.date.available2025-10-21T19:16:37Z-
dc.date.issued2013-08-
dc.identifier.citationBARBOSA, F. F. et al. Differential cortical c-Fos and Zif-268 expression after object and spatial memory processing in a standard or episodic-like object recognition task. Frontiers in Behavioral Neuroscience, Lausanne, v. 7, n. 112, ago. 2013. Disponível em: https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2013.00112/full. Acesso em: 21 out. 2025.pt_BR
dc.identifier.issn1662-5153-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/23591-
dc.languageengpt_BR
dc.publisherFrontiers Media S. A.pt_BR
dc.relation.ispartofFrontiers in Behavioral Neurosciencept_BR
dc.subjectRecognition memoryeng
dc.subjectSpatial memoryeng
dc.subjectEpisodic memoryeng
dc.subjectImmediate early geneseng
dc.subjectPlasticityeng
dc.subjectHippocampuseng
dc.titleDifferential cortical c-Fos and Zif-268 expression after object and spatial memory processing in a standard or episodic-like object recognition taskpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição-NãoComercial 3.0 Não Adaptada (CC BY-NC 3.0)pt_BR
dc.description.resumoEpisodic memory reflects the capacity to recollect what, where, and when a specific event happened in an integrative manner. Animal studies have suggested that the medial temporal lobe and the medial pre-frontal cortex are important for episodic-like memory (ELM) formation.The goal of present study was to evaluate whether there are different patterns of expression of the immediate early genes c-Fos and Zif-268 in these cortical areas after rats are exposed to object recognition (OR) tasks with different cognitive demands. Male rats were randomly assigned to five groups: home cage control, empty open field (CTR-OF), open field with one object (CTR-OF + Obj), novel OR task, and ELM task and were killed 1 h after the last behavioral procedure. Rats were able to discriminate the objects in the OR task. In the ELM task, rats showed spatial (but not temporal) discrimination of the objects. We found an increase in the c-Fos expression in the dorsal dentate gyrus (DG) and in the perirhinal cortex (PRh) in the OR and ELM groups.The OR group also presented an increase of c-Fos expression in the medial prefrontal cortex (mPFC). Additionally, the OR and ELM groups had increased expression of Zif-268 in the mPFC. Moreover, Zif-268 was increased in the dorsal CA1 and PRh only in the ELM group. In conclusion, the pattern of activation was different in tasks with different cognitive demands. Accordingly, correlation tests suggest the engagement of different neural networks in the tasks used. Specifically, perirhinal-DG co-activation was detected after the what-where memory retrieval, but not after the novel OR task. Both regions correlated with the respective behavioral outcome. These findings can be helpful in the understanding of the neural networks underlying memory tasks with different cognitive demands.pt_BR
dc.description.localLausannept_BR
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