1. Repositório Institucional da Universidade Federal de Sergipe - RI/UFS
  2. PRODUÇÃO CIENTÍFICA
  3. DFS - Departamento de Fisiologia
  4. DFS - Artigos de periódicos
Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/23816
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorLeite, Camila Ferreira-
dc.contributor.authorMarangoni, Fábio André-
dc.contributor.authorCamargo, Enilton Aparecido-
dc.contributor.authorBraga, Angélica de Fátima de Assunção-
dc.contributor.authorToro, Ivan Felizardo Contrera-
dc.contributor.authorAntunes, Edson-
dc.contributor.authorLanducci, Elen Cristina Tiezem-
dc.contributor.authorMussi, Ricardo Kalaf-
dc.date.accessioned2025-11-10T20:32:56Z-
dc.date.available2025-11-10T20:32:56Z-
dc.date.issued2013-
dc.identifier.citationLEITE, C. F. et al. Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 4, p. 245-250, 2013. Disponível em: https://www.scielo.br/j/acb/a/tKKdFYDKb6kFRx7R3dHCVDK/?lang=en. Acesso em: 10 nov. 2025.pt_BR
dc.identifier.issn1678-2674-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/23816-
dc.languageengpt_BR
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgiapt_BR
dc.relation.ispartofActa Cirúrgica Brasileirapt_BR
dc.subjectAnimals modelseng
dc.subjectPulmonary ventilationeng
dc.subjectSimvastatineng
dc.subjectThoracic Surgeryeng
dc.subjectInflammationeng
dc.subjectRatseng
dc.titleSimvastatin attenuates neutrophil recruitment in one-lung ventilation model in ratspt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0)pt_BR
dc.description.resumoPURPOSE: To investigate the anti-inflammatory effects of simvastatin in rats undergoing one-lung ventilation (OLV) followed by lung re-expansion. METHODS: Male Wistar rats (n=30) were submitted to 1-h OLV followed by 1-h lung re-expansion. Treated group received simvastatin (40 mg/kg for 21 days) previous to OLV protocol. Control group received no treatment or surgical/ventilation interventions. Measurements of pulmonary myeloperoxidase (MPO) activity, pulmonary protein extravasation, and serum levels of cytokines and C-reactive protein (CRP) were performed. RESULTS: OLV significantly increased the MPO activity in the collapsed and continuously ventilated lungs (31% and 52% increase, respectively) compared with control (p<0.05). Treatment with simvastatin significantly reduced the MPO activity in the continuously ventilated lung but had no effect on lung edema after OLV. The serum IL-6 and CRP levels were markedly higher in OLV group, but simvastatin treatment failed to affect the production of these inflammatory markers. Serum levels of IL-1β, TNF-α and IL-10 remained below the detection limit in all groups. CONCLUSIONS: In an experimental one-lung ventilation model pre-operative treatment with simvastatin reduces remote neutrophil infiltration in the continuously ventilated lung. Our findings suggest that simvastatin may be of therapeutic value in OLV-induced pulmonary inflammation deserving clinical investigations.pt_BR
dc.description.localSão Paulopt_BR
Aparece nas coleções:DFS - Artigos de periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
SimvastatinNeutrophilRecruitmentOneLungVentilation.pdf346,33 kBAdobe PDFThumbnail
Visualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.