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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/23841
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dc.contributor.authorMorais, Janaína Pereira-
dc.contributor.authorPereira, Denyson Santana-
dc.contributor.authorMatos, Alexandre Santos-
dc.contributor.authorSantana, Danielle Gomes-
dc.contributor.authorSantos, Cliomar Alves dos-
dc.contributor.authorEstevam, Charles dos Santos-
dc.contributor.authorFakhouri, Ricardo-
dc.contributor.authorDe Lucca Junior, Waldecy-
dc.contributor.authorCamargo, Enilton Aparecido-
dc.date.accessioned2025-11-12T19:02:49Z-
dc.date.available2025-11-12T19:02:49Z-
dc.date.issued2013-
dc.identifier.citationMORAIS, J. P. et al. The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats. The Scientific World Journal, New York, n. 1, 2013. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1155/2013/694010. Acesso em: 12 nov. 2025.pt_BR
dc.identifier.issn1537-744X-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/23841-
dc.languageengpt_BR
dc.publisherHindawi Publishing Corporationpt_BR
dc.relation.ispartofThe Scientific World Journalpt_BR
dc.subjectHemorrhagic cystitiseng
dc.subjectCyclophosphamide therapyeng
dc.subjectEthanol extracteng
dc.subjectCaesalpinia pyramidaliseng
dc.titleThe ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in ratspt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)pt_BR
dc.description.resumoHemorrhagic cystitis (HC) is a common side effect of cyclophosphamide therapy, which deserves new therapeutic strategies, such as those based on natural products. The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) (EECp) possesses anti-inflammatory, antinociceptive, and antioxidant activities as previously showed by our group. We have investigated the effect of EECp on the cyclophosphamide-induced HC. Cystitis was induced in male Wistar rats by the injection of cyclophosphamide. These animals were pretreated with EECp (100–400 mg/kg), vehicle, or mesna. Myeloperoxidase activity and malondialdehyde formation were measured in urinary bladder and other tissues. Bladder edema and histopathological alterations and serum nitric oxide metabolites concentration mathematical equation were also evaluated. Treatment with EECp (100–400 mg/kg) or mesna impaired the increase of myeloperoxidase activity in urinary bladder and the serum mathematical equation induced by cyclophosphamide but did not reduce edema in this tissue, as did mesna. Total histological score was reduced by EECp (100 mg/kg). Lung myeloperoxidase activity, which was increased by cyclophosphamide, was decreased significantly by EECp (400 mg/kg). EECp also diminished the malondialdehyde formation in bladder, lung, and spleen, although these parameters were not affected by cyclophosphamide. These results indicate that EECp reduced urinary bladder damage during cyclophosphamide-induced HC in rats.pt_BR
dc.description.localNew Yorkpt_BR
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