Análise do fenótipo muscular lombar em indivíduos com Digh no município de Itabaianinha Sergipe

Abstract

The lumbar spine is a spinal axis commonly affected by pain in most people. In Itabaianinha, in the interior of Sergipe, there is a population with GH hormone deficiency due to a mutation in the GHRH-R gene. It is important to mention that the scientific literature still does not have clear data regarding the analysis of strength and resistance of the lumbar spine in this population, therefore, this study aims to analyze the muscular phenotype with characteristics of strength and resistance of the lumbar spine in individuals with GH and IGF-I deficiency. The probability of early low back pain, isometric relationship of trunk extensors with nonspecific low back pain, quantification of muscle action potential using, respectively, the Roland Morris Disability Questionnaire, Sorensen Test and electromyographic parameters were evaluated. This is an analytical, observational and cross-sectional study that will compare the DIGH group (GHRH-R c.57 + 1G>A), vs. Control Group (CG), of both sexes aged 18 years and over, matched by age, sex, BMI and dexterity. The data were analyzed by the free software JAMOVI® version 2.3 for Windows® and were used for a significance level of 5% at p<0.05, with 95% confidence intervals. The Shapiro-Wilk test was used to test the normality of the data distribution. The t-test for independent samples was used for parametric data and the Man-Whitney test for nonparametric data. It was observed that the DIGH group, compared to the control group, presented a higher value for myoelectric activity, with a significant difference for the right spinal muscles (79.1±5.2 vs. 65.6±4.0) (p˂0.050) (CI: -27.0-0.14) and a higher value for conduction velocity with a significant difference in the right spinal muscle region (164.2±10.05 vs. 122.5±6.3) (p˂ (0.002) (CI: -66.79-16.71). Regarding the analysis of MVIC, left spinal myoelectric activity, fractal dimension and conduction velocity parameters of the left spinal muscles, there is no difference between the groups. Thus, the results point to a greater resistance to peripheral fatigue in the right spinal muscles in the DIGH group and greater right muscle electrical activity by EMG, in addition to better results pertinent to functionality and pain index.