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Tipo de Documento:	Artigo
Título:	Determinants of intensive insulin therapeutic regimens in patients with type 1 diabetes: data from a nationwide multicenter survey in Brazil
Autor(es):	Gomes, Marilia Brito Negrato, Carlos Antônio Cobas, Roberta Tannus, Lucianne Righeti Monteiro Gonçalves, Paolla Ribeiro Silva, Pedro Carlos Barreto da Carneiro, João Regis Ivar Matheus, Alessandra Saldanha Mattos Dib, Sergio Atala Azevedo, Mirela Jobim Nery, Márcia Rodacki, Melanie Zajdenverg, Lenita Montenegro Junior, Renan Magalhães Sepulveda, Janice Calliari, Luis Eduardo Jezini, Deborah Braga, Neuza Luescher, Jorge Luiz Berardo, Renata Szundy Arruda-Marques, Maria Carmo Noronha, Renata M. Manna, Thais Della Salvodelli, Roberta Penha, Fernanda G. Foss, Milton Cesar Freitas, Maria Cristina Foss de Pires, Antônio C. Robles, Fernando Cesar Guedes, Maria de Fátima S. Dualib, Patricia Medici Silva, Saulo C. Sampaio, Emerson Rea, Rosangela Faria, Ana Cristina R. Tschiedel, Balduino Lavigne, Suzana Canani, Luis Henrique Zucatti, Alessandra T. Coral, Marisa Helena Cesar Pereira, Daniela Aline Araujo, Luiz Antonio Tolentino, Monica Pedrosa, Hermelinda Cordeiro Prado, Flaviane A. Rassi, Nelson Araujo, Leticia B. Fonseca, Reine Marie Chaves Guedes, Alexis D. Matos, Odelissa S. Palma, Catia C. Azulay, Rossana Costa e Forti, Adriana Façanha, Cristina Montenegro, Ana Paula Melo, Naira Horta Rezende, Karla Freire Ramos, Alberto Felicio, João Soares Santos, Flavia Marques
Data do documento:	2014
Resumo:	Background: To evaluate the determinants of intensive insulin regimens (ITs) in patients with type 1 diabetes (T1D). Methods: This multicenter study was conducted between December 2008 and December 2010 in 28 public clinics in 20 Brazilian cities. Data were obtained from 3,591 patients (56.0% female, 57.1% Caucasian). Insulin regimens were classified as follows: group 1, conventional therapy (CT) (intermediate human insulin, one to two injections daily); group 2 (three or more insulin injections of intermediate plus regular human insulin); group 3 (three or more insulin injections of intermediate human insulin plus short-acting insulin analogues); group 4, basal-bolus (one or two insulin injections of long-acting plus short-acting insulin analogues or regular insulin); and group 5, basal-bolus with continuous subcutaneous insulin infusion (CSII). Groups 2 to 5 were considered IT groups. Results: We obtained complete data from 2,961 patients. Combined intermediate plus regular human insulin was the most used therapeutic regimen. CSII was used by 37 (1.2%) patients and IT by 2,669 (90.2%) patients. More patients on IT performed self-monitoring of blood glucose and were treated at the tertiary care level compared to CT patients (p < 0.001). The majority of patients from all groups had HbA1c levels above the target. Overweight or obesity was not associated with insulin regimen. Logistic regression analysis showed that economic status, age, ethnicity, and level of care were associated with IT (p < 0.001). Conclusions: Given the prevalence of intensive treatment for T1D in Brazil, more effective therapeutic strategies are needed for long term-health benefits.
Palavras-chave:	Type 1 diabetes Chronic complications Insulin regimens Brazil
ISSN:	1758-5996
Parte de :	Diabetology and metabolic syndrome
Idioma:	eng
Instituição/Editora:	BioMed Central
Citação:	GOMES, M. B. et al. Determinants of intensive insulin therapeutic regimens in patients with type 1 diabetes: data from a nationwide multicenter survey in Brazil. Diabetology and metabolic syndrome, London, v. 6, n. 67, 2014. Disponível em: https://link.springer.com/article/10.1186/1758-5996-6-67. Acesso em: 26 jan. 2026.
Licença:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identificador:	https://doi.org/10.1186/1758-5996-6-67
URI:	https://ri.ufs.br/jspui/handle/riufs/24393
Aparece nas coleções:	DME - Artigos de periódicos

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