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https://ri.ufs.br/jspui/handle/riufs/25058| Tipo de Documento: | Artigo |
| Título: | Left ventricular hypertrophy in children, adolescents and young adults with sickle cell anemia |
| Autor(es): | Faro, Gustavo Baptista de Almeida Menezes Neto, Osvaldo Alves Batista, Geodete Santos Silva Neto, Antônio Pereira Cipolotti, Rosana |
| Data do documento: | 2015 |
| Resumo: | Objective: The aims of this study were to estimate the frequency of left ventricular hypertrophy and to identify variables associated with this condition in under 25-year-old patients with sickle cell anemia. Methods: A cross-sectional study was performed of children, adolescents and young adults with sickle cell anemia submitted to a transthoracic Doppler echocardiography. The mass of the left ventricle was determined by the formula of Devereux et al. with correction for height, and the percentile curves of gender and age were applied. Individuals with rheumatic and congenital heart disease were excluded. The patients were divided into two groups according to the presence or absence ofleft ventricular hypertrophy and compared according to clinical, echocardiographic and laboratory variables. Results: A total of 37.6% ofthe patients had left ventricular hypertrophy in this sample. There was no difference between the groups of patients with and without hypertrophy according to pathological history or clinical characteristics, except possibly for the use of hydroxyurea, more often used in the group without left ventricular hypertrophy. Patients with left ventricular hypertrophy presented larger left atria and lower hemoglobin and hematocrit levels, reticulocyte index and a higher albumin:creatinine ratio in urine. Conclusion: Left ventricular hypertrophy was observed in more than one-third of the young patients with sickle cell anemia with this finding being inversely correlated to the hemoglobin and hematocrit levels, and reticulocyte index and directly associated to a higher albumin/creatinine ratio. It is possible that hydroxyurea had had a protective effect on the development of left ventricular hypertrophy. |
| Palavras-chave: | Sickle cell anemia Left ventricular function Left ventricular dysfunction Echocardiography |
| ISSN: | 1516-8484 |
| Parte de : | Revista Brasileira de Hematologia e Hemoterapia |
| Idioma: | eng |
| Instituição/Editora: | Sociedade Brasileira de Hematologia e Hemoterapia |
| Citação: | FARO, G. B. A. et al. Left ventricular hypertrophy in children, adolescents and young adults with sickle cell anemia. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 37, n. 5, 2015. Disponível em: https://www.sciencedirect.com/science/article/pii/S1516848415001073?via%3Dihub. Acesso em: 23 mar. 2026. |
| Licença: | Creative Commons Atribuição-Não Comercial-Sem Derivações 4.0 Internacional (CC BY-NC-ND 4.0) |
| URI: | https://ri.ufs.br/jspui/handle/riufs/25058 |
| Aparece nas coleções: | DME - Artigos de periódicos |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| LeftVentricularHypertrophySickleCellAnemia.pdf | 527,97 kB | Adobe PDF | Visualizar/Abrir |
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