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Please use this identifier to cite or link to this item: https://ri.ufs.br/jspui/handle/riufs/25120
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dc.contributor.authorSalgado, Paula Regina Rodrigues-
dc.contributor.authorFonsêca, Diogo Vilar da-
dc.contributor.authorBraga, Renan Marinho-
dc.contributor.authorMelo, Cynthia Germoglio Farias de-
dc.contributor.authorAndrade, Luciana Nalone-
dc.contributor.authorAlmeida, Reinaldo Nóbrega de-
dc.contributor.authorSousa, Damião Pergentino de-
dc.date.accessioned2026-07-06T18:33:33Z-
dc.date.available2026-07-06T18:33:33Z-
dc.date.issued2015-
dc.identifier.citationSALGADO, P. R. R. et al. Comparative anticonvulsant study of epoxycarvone stereoisomers. Molecules, Basel, v. 20, n. 11, p. 19660-19673, 2015. Disponível em: https://www.mdpi.com/1420-3049/20/11/19649. Acesso em: 29 abr. 2026.pt_BR
dc.identifier.issn1420-3049-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25120-
dc.languageengpt_BR
dc.publisherMDPIpt_BR
dc.relation.ispartofMoleculespt_BR
dc.subjectAnticonvulsanteng
dc.subjectCarvoneeng
dc.subjectStereoisomerseng
dc.subjectTerpeneeng
dc.subjectNatural productseng
dc.subjectEssential oilseng
dc.subjectPentylenetetrazoleeng
dc.subjectSeizureseng
dc.subjectPara-menthaneseng
dc.subjectEnantiomerseng
dc.titleComparative anticonvulsant study of epoxycarvone stereoisomerspt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoStereoisomers of the monoterpene epoxycarvone (EC), namely (+)-cis-EC, (´)-cis-EC, (+)-trans-EC, and (´)-trans-EC, were comparatively evaluated for anticonvulsant activity in specific methodologies. In the pentylenetetrazole (PTZ)-induced anticonvulsant test, all of the stereoisomers (at 300 mg/kg) increased the latency to seizure onset, and afforded 100% protection against the death of the animals. In the maximal electroshock-induced seizures (MES) test, prevention of tonic seizures was also verified for all of the isomers tested. However, the isomeric forms (+) and (´)-trans-EC showed 25% and 12.5% inhibition of convulsions, respectively. In the pilocarpine-induced seizures test, all stereoisomers demonstrated an anticonvulsant profile, yet the stereoisomers (+) and (´)-trans-EC (at 300 mg/kg) showed a more pronounced effect. A strychnine-induced anticonvulsant test was performed, and none of the stereoisomers significantly increased the latency to onset of convulsions; the stereoisomers probably do not act in this pathway. However, the stereoisomers (+)-cis-EC and (+)-trans-EC greatly increased the latency to death of the animals, thus presenting some protection. The four EC stereoisomers show promise for anticonvulsant activity, an effect emphasized in the isomers (+)-cis-EC, (+)-trans-EC, and (´)-trans-EC for certain parameters of the tested methodologies. These results serve as support for further research and development of antiepileptic drugs from monoterpenes.pt_BR
dc.description.localBaselpt_BR
dc.identifier.doihttps://doi.org/10.3390/molecules201119649-
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