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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25143
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dc.contributor.authorSilva, Martapolyana Torres Menezes da-
dc.contributor.authorRibeiro, Fernanda Pires Rodrigues de Almeida-
dc.contributor.authorMedeiros, Maria Alice Miranda Bezerra-
dc.contributor.authorSampaio, Pedrita Alves-
dc.contributor.authorSilva, Yonara M. S.-
dc.contributor.authorSilva, Morganna Thinesca Almeida-
dc.contributor.authorQuintans, Jullyana de Souza Siqueira-
dc.contributor.authorQuintans Júnior, Lucindo José-
dc.contributor.authorRibeiro, Luciano Augusto de Araújo-
dc.date.accessioned2026-07-06T18:38:25Z-
dc.date.available2026-07-06T18:38:25Z-
dc.date.issued2015-
dc.identifier.citationSILVA, M. T. M. et al. The vasorelaxant effect of p-Cymene in rat aorta involves potassium channels. The Scientific World Journal, New York, n. 1, 2015. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2015/458080. Acesso em: 8 maio 2026.pt_BR
dc.identifier.issn1537-744X-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25143-
dc.languageengpt_BR
dc.publisherHindawi Publishing Corporationpt_BR
dc.relation.ispartofThe Scientific World Journalpt_BR
dc.subjectMonoterpeneseng
dc.subjectP-cymeneeng
dc.subjectAntinociceptive and anti-inflammatory activitieseng
dc.titleThe vasorelaxant effect of p-Cymene in rat aorta involves potassium channelspt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)pt_BR
dc.description.resumoThe monoterpenes are the main constituents of most essential oils and p-cymene is a monoterpene commonly found in various species of aromatic herbs, which has been reported for anti-inflammatory, antinociceptive, and antimicrobial activities. However,there is no report concerning its pharmacological activity on the vascular smooth muscle. The aim of current work was to investigatethe effects of p-cymene in isolated rat aorta and also study its mechanism of action. In this work, we show that p-cymene has arelaxant effect, in a dose-dependent way, on the vascular smooth muscle, regardless of the presence of the endothelium. Using anonselective potassium channel blocker, the CsCl, the relaxant effect of p-cymene was attenuated. In the presence of more selectivepotassium channels blockers, such as TEA or 4-AP, no change in the relaxant effect of p-cymene was evidenced, indicating thatBKCa and K V channels are not involved in that relaxant effect. However, in the presence of glibenclamide or BaCl2, KATP and K irblockers, respectively, the relaxant effect of p-cymene was attenuated. The data presented indicate that p-cymene has a relaxingeffect on rat aorta, regardless of the endothelium, but with the participation of the KATP and Kir channels.pt_BR
dc.description.localNew Yorkpt_BR
dc.identifier.doihttps://doi.org/10.1155%2F2015%2F458080-
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