1. Repositório Institucional da Universidade Federal de Sergipe - RI/UFS
  2. PRODUÇÃO CIENTÍFICA
  3. DFS - Departamento de Fisiologia
  4. DFS - Artigos de periódicos
Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25165
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorAndrade, Luciana Nalone-
dc.contributor.authorAmaral, Ricardo Guimarães-
dc.contributor.authorDória, Grace Anne Azevedo-
dc.contributor.authorFonseca, Cecília Santos-
dc.contributor.authorSilva, Tayane Kayane Mariano da-
dc.contributor.authorAlbuquerque Júnior, Ricardo Luiz Cavalcante-
dc.contributor.authorThomazzi, Sara Maria-
dc.contributor.authorNascimento, Lázaro Gomes do-
dc.contributor.authorCarvalho, Adriana Andrade-
dc.contributor.authorSousa, Damião Pergentino de-
dc.date.accessioned2026-07-06T19:02:46Z-
dc.date.available2026-07-06T19:02:46Z-
dc.date.issued2016-
dc.identifier.citationANDRADE, L. N. et al. In vivo anti-tumor activity and toxicological evaluations of perillaldehyde 8,9-epoxide, a derivative of perillyl alcohol. International Journal of Molecular Sciences, Basel, v. 17, n. 1, 2016. Disponível em: https://www.mdpi.com/1422-0067/17/1/32. Acesso em: 21 maio 2026.pt_BR
dc.identifier.issn1422-0067-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25165-
dc.languageengpt_BR
dc.publisherMDPI Centerpt_BR
dc.relation.ispartofInternational Journal of Molecular Sciencespt_BR
dc.subjectP-menthaneseng
dc.subjectMonoterpeneseng
dc.subjectEssential oilseng
dc.subjectNatural productseng
dc.subjectAntitumor activityeng
dc.subjectSarcoma 180eng
dc.subjectToxicityeng
dc.subjectAnticancereng
dc.subjectPerillyl alcoholeng
dc.titleIn vivo anti-tumor activity and toxicological evaluations of perillaldehyde 8,9-epoxide, a derivative of perillyl alcoholpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoRecent studies have revealed the high cytotoxicity of p-menthane derivatives against human tumor cells. In this study, the substance perillaldehyde 8,9-epoxide, a p-menthane class derivative obtained from (S)-(´)-perillyl alcohol, was selected in order to assess antitumor activity against experimental sarcoma 180 tumors. Toxicological effects related to the liver, spleen, kidneys and hematology were evaluated in mice submitted to treatment. The tumor growth inhibition rate was 38.4%, 58.7%, 35.3%, 45.4% and 68.1% at doses of 100 and 200 mg/kg/day for perillaldehyde 8,9-epoxide, perillyl alcohol and 25 mg/kg/day for 5-FU intraperitoneal treatments, respectively. No toxicologically significant effect was found in liver and kidney parameters analyzed in Sarcoma 180-inoculated mice treated with perillaldehyde 8,9-epoxide. Histopathological analyses of the liver, spleen, and kidneys were free from any morphological changes in the organs of the animals treated with perillaldehyde 8,9-epoxide. In conclusion, the data suggest that perillaldehyde 8,9-epoxide possesses significant antitumor activity without systemic toxicity for the tested parameters. By comparison, there was no statistical difference for the antitumor activity between perillaldehyde 8,9-epoxide and perillyl alcohol.pt_BR
dc.description.localBaselpt_BR
dc.identifier.doihttps://doi.org/10.3390/ijms17010032-
Aparece nas coleções:DFS - Artigos de periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
InVivoAntitumorActivityToxicologicalEvaluations.pdf9,37 MBAdobe PDFThumbnail
Visualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.