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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25180
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dc.contributor.authorCassiano, Gustavo Capatti-
dc.contributor.authorFurini, Adriana Antônia da Cruz-
dc.contributor.authorCapobianco, Marcela Petrolini-
dc.contributor.authorMelo, Luciane Moreno Storti de-
dc.contributor.authorAlmeida, Maria Edilene Martins de-
dc.contributor.authorBarbosa, Danielle Regina Lima-
dc.contributor.authorPóvoa, Marinete Marins-
dc.contributor.authorNogueira, Paulo Afonso-
dc.contributor.authorMachado, Ricardo Luiz Dantas-
dc.date.accessioned2026-07-06T19:06:40Z-
dc.date.available2026-07-06T19:06:40Z-
dc.date.issued2016-
dc.identifier.citationCASSIANO, G. C. et al. Immunogenetic markers associated with a naturally acquired humoral immune response against an N-terminal antigen of Plasmodium vivax merozoite surface protein 1 (PvMSP-1). Malaria journal, London, v. 15, n. 306, 2016. Disponível em: https://link.springer.com/article/10.1186/s12936-016-1350-2. Acesso em: 26 maio 2026.pt_BR
dc.identifier.issn1475-2875-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25180-
dc.languageengpt_BR
dc.publisherBioMed Centralpt_BR
dc.relation.ispartofMalaria journalpt_BR
dc.subjectPlasmodium vivaxeng
dc.subjectMSP-1eng
dc.subjectICB2-5eng
dc.subjectImmunogeneticseng
dc.subjectAntibodieseng
dc.titleImmunogenetic markers associated with a naturally acquired humoral immune response against an N-terminal antigen of Plasmodium vivax merozoite surface protein 1 (PvMSP-1)pt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoBackground: Humoral immune responses against proteins of asexual blood-stage malaria parasites have been associated with clinical immunity. However, variations in the antibody-driven responses may be associated with a genetic component of the human host. The objective of the present study was to evaluate the influence of co-stimulatory molecule gene polymorphisms of the immune system on the magnitude of the humoral immune response against a Plasmodium vivax vaccine candidate antigen. Methods: Polymorphisms in the CD28, CTLA4, ICOS, CD40, CD86 and BLYS genes of 178 subjects infected with P. vivax in an endemic area of the Brazilian Amazon were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The levels of IgM, total IgG and IgG subclasses specific for ICB2-5, i.e., the N-terminal portion of P. vivax merozoite surface protein 1 (PvMSP-1), were determined by enzyme-linked immuno assay. The associations between the polymorphisms and the antibody response were assessed by means of logistic regression models. Results: After correcting for multiple testing, the IgG1 levels were significantly higher in individuals recessive for the single nucleotide polymorphism rs3116496 in CD28 (p = 0.00004). Furthermore, the interaction between CD28 rs35593994 and BLYS rs9514828 had an influence on the IgM levels (p = 0.0009). Conclusions: The results of the present study support the hypothesis that polymorphisms in the genes of costimulatory components of the immune system can contribute to a natural antibody-driven response against P. vivax antigens.pt_BR
dc.description.localLondonpt_BR
dc.identifier.doihttps://doi.org/10.1186/s12936-016-1350-2-
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