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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25337
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dc.contributor.authorFurini, Adriana Antônia da Cruz-
dc.contributor.authorCapobianco, Marcela Petrolini-
dc.contributor.authorMelo, Luciane Moreno Storti de-
dc.contributor.authorCunha, Maristela Gomes da-
dc.contributor.authorCassiano, Gustavo Capatti-
dc.contributor.authorMachado, Ricardo Luiz Dantas-
dc.date.accessioned2026-07-07T17:44:20Z-
dc.date.available2026-07-07T17:44:20Z-
dc.date.issued2016-
dc.identifier.citationFURINI, A. A. C. et al. Cytokine gene polymorphisms are not associated with anti-PvDBP, anti-PvAMA-1 or anti-PvMSP-119 IgG antibody levels in a malaria-endemic area of the Brazilian Amazon. Malaria journal, London, v. 15, n. 374, 2016. Disponível em: https://link.springer.com/article/10.1186/s12936-016-1414-3. Acesso em: 7 jul. 2026.pt_BR
dc.identifier.issn1475-2875-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25337-
dc.languageengpt_BR
dc.publisherBioMed Centralpt_BR
dc.relation.ispartofMalaria journalpt_BR
dc.subjectIgG antibodyeng
dc.subjectPlasmodium vivaxeng
dc.subjectTNF, IFNG, IL10eng
dc.titleCytokine gene polymorphisms are not associated with anti-PvDBP, anti-PvAMA-1 or anti-PvMSP-119 IgG antibody levels in a malaria-endemic area of the Brazilian Amazonpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoBackground: The immune response against Plasmodium vivax immunogenic epitopes is regulated by pro- and anti-inflammatory cytokines that determine antibody levels and class switching. Cytokine gene polymorphisms may be responsible for changes in the humoral immune response against malaria. The aim of this study was to evaluate whether polymorphisms in the TNFA, IFNG and IL10 genes would alter the levels of anti-PvAMA1, PvDBP and -PvMSP119 IgG antibodies in patients with vivax malaria. Methods: Samples from 90 vivax malaria-infected and 51 uninfected subjects from an endemic area of the Brazilian Amazon were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) to identify polymorphisms of the genes TNFA (−1031T > C, −308G > A, −238G > A), IFNG (+874T > A) and IL10 (−819C > T, −592C > A). The levels of total IgG against PvAMA1, PvDBP and PvMSP-119 were determined using an enzyme-linked immunosorbent assay (ELISA). Associations between the polymorphisms and the antibody response were assessed by means of logistic regression models. Results: No significant differences were found in the levels of IgG antibodies against the PvAMA-1, PvDBP or PvMSP119 proteins in relation to the studied polymorphisms. Conclusions: Although no associations were found among the evaluated genotypes and alleles and anti-merozoite IgG class P. vivax antibody levels, this study helps elucidate the immunogenic profile involved in the humoral immune response in malaria.pt_BR
dc.description.localLondonpt_BR
dc.identifier.doihttps://doi.org/10.1186/s12936-016-1414-3-
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