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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25546
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dc.contributor.authorVenancio, Antonio Medeiros-
dc.contributor.authorFerreira da Silva, Francisco Walber-
dc.contributor.authorSilva-Alves, Kerly Shamyra da-
dc.contributor.authorPimentel, Hugo de Carvalho-
dc.contributor.authorLima, Matheus Macêdo-
dc.contributor.authorSantana, Michele Fraga de-
dc.contributor.authorAlves, Péricles Barreto-
dc.contributor.authorSilva, Givanildo Batista da-
dc.contributor.authorLeal-Cardoso, José Henrique-
dc.contributor.authorMarchioro, Murilo-
dc.date.accessioned2026-07-14T20:15:45Z-
dc.date.available2026-07-14T20:15:45Z-
dc.date.issued2016-
dc.identifier.citationVENANCIO, A. M. et al. Essential oil of Ocimum basilicum L. and (−)-Linalool blocks the excitability of rat sciatic nerve. Evidence-Based Complementary and Alternative Medicine, New York, n. 1, 2016. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2016/9012605. Acesso em: 14 jul. 2026.pt_BR
dc.identifier.issn1741-4288-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25546-
dc.languageengpt_BR
dc.publisherHindawi Publishing Corporationpt_BR
dc.relation.ispartofEvidence-Based Complementary and Alternative Medicinept_BR
dc.subjectLinalooleng
dc.subjectEssential oilseng
dc.subjectRat sciatic nerveeng
dc.subjectPeripheral nervous systemeng
dc.subjectExcitabilityeng
dc.titleEssential oil of Ocimum basilicum L. and (−)-Linalool blocks the excitability of rat sciatic nervept_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoThe racemate linalool and its levogyrus enantiomer [(−)-LIN] are present in many essential oils and possess several pharmacological activities, such as antinociceptive and anti-inflammatory. In this work, the effects of essential oil obtained from the cultivation of the Ocimum basilicum L. (EOOb) derived from Germplasm Bank rich in (−)-LIN content in the excitability of peripheral nervous system were studied. We used rat sciatic nerve to investigate the EOOb and (−)-LIN effects on neuron excitability and the extracellular recording technique was used to register the compound action potential (CAP). EOOb and (−)-LIN blocked the CAP in a concentration-dependent way and these effects were reversible after washout. EOOb blocked positive amplitude of 1st and 2nd CAP components with IC50 of 0.38 ± 0.2 and 0.17 ± 0.0 mg/mL, respectively. For (−)-LIN, these values were 0.23 ± 0.0 and 0.13 ± 0.0 mg/mL. Both components reduced the conduction velocity of CAP and the 2nd component seems to be more affected than the 1st component. In conclusion EOOb and (−)-LIN inhibited the excitability of peripheral nervous system in a similar way and potency, revealing that the effects of EOOb on excitability are due to the presence of (−)-LIN in the essential oil.pt_BR
dc.description.localNew Yorkpt_BR
dc.identifier.doihttps://doi.org/10.1155/2016/9012605-
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