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Tipo de Documento:	Artigo
Título:	Baseline characteristics and risk factors for ulcer, amputation and severe neuropathy in diabetic foot at risk: the BRAZUPA study
Autor(es):	Parisi, Maria Candida R. Moura Neto, Arnaldo Menezes, Fabio H. Gomes, Marilia Brito Teixeira, Rodrigo Martins Oliveira, José Egídio Paulo de Pereira, Joana Rodrigues Dantas Fonseca, Reine Marie Chaves Guedes, Lorena Barreto Arruda Costa e Forti, Adriana Oliveira, Ana Mayra Andrade de Nóbrega, Marta Barreto de Medeiros Colares, Víctor Nóbrega Quintas Schmid, Helena Nienov, Otto Henrique Nery, Marcia Fernandes, Túlio Diniz Pedrosa, Hermelinda C. Oliveira, Cristina da S. Schreiber de Ronsoni, Marcelo Rezende, Karla Freire Quilici, Maria Teresa Verrone Vieira, Alexandre Eduardo Franzin Macedo, Geisa Maria Campos de Stuchi‑Perez, Eliana Gabas Dinhane, Kandir Genésio Innocenti Pace, Ana Emilia Freitas, Maria Cristina Foss de Calsolari, Maria Regina Saad, Mario José Abdalla
Data do documento:	2016
Resumo:	Background: Studies on diabetic foot and its complications involving a significant and representative sample of patients in South American countries are scarce. The main objective of this study was to acquire clinical and epide‑ miological data on a large cohort of diabetic patients from 19 centers from Brazil and focus on factors that could be associated with the risk of ulcer and amputation. Methods: This study presents cross sectional, baseline results of the BRAZUPA Study. A total of 1455 patients were included. Parameters recorded included age, gender, ethnicity, diabetes and comorbidity-related records, previous ulcer or amputation, clinical symptomatic score, foot classification and microvascular complications. Results: Patients with ulcer had longer disease duration (17.2 ± 9.9 vs. 13.2 ± 9.4 years; p < 0.001), and poorer gly‑ cemic control (HbA1c 9.23 ± 2.03 vs. 8.35 ± 1.99; p < 0.001). Independent risk factors for ulcer were male gender (OR 1.71; 95 % CI 1.2–3.7), smoking (OR 1.78; 95 % CI 1.09–2.89), neuroischemic foot (OR 20.34; 95 % CI 9.31–44.38), region of origin (higher risk for those from developed regions, OR 2.39; 95 % CI 1.47–3.87), presence of retinopathy (OR 1.68; 95 % CI 1.08–2.62) and absence of vibratory sensation (OR 7.95; 95 % CI 4.65–13.59). Risk factors for amputation were male gender (OR 2.12; 95 % CI 1.2–3.73), type 2 diabetes (OR 3.33; 95 % CI 1.01–11.1), foot at risk classification (higher risk for ischemic foot, OR 19.63; 95 % CI 3.43–112.5), hypertension (lower risk, OR 0.3; 95 % CI 0.14–0.63), region of origin (South/Southeast, OR 2.2; 95 % CI 1.1–4.42), previous history of ulcer (OR 9.66; 95 % CI 4.67–19.98) and altered vibratory sensation (OR 3.46; 95 % CI 1.64–7.33). There was no association between either outcome and ethnicity. Conclusions: Ulcer and amputation rates were high. Age at presentation was low and patients with ulcer presented a higher prevalence of neuropathy compared to ischemic foot at risk. Ischemic disease was more associated with amputations. Ethnical differences were not of great importance in a miscegenated population.
Palavras-chave:	Diabetes Risk factors for ulcer Amputation Severe neuropathy Brazil
ISSN:	1758-5996 https://doi.org/10.1186/s13098-016-0126-8
Parte de :	Diabetology & Metabolic Syndrome
Idioma:	eng
Instituição/Editora:	BioMed Central
Citação:	PARISI, M. C. R. et al. Baseline characteristics and risk factors for ulcer, amputation and severe neuropathy in diabetic foot at risk: the BRAZUPA study. Diabetology & Metabolic Syndrome, London, v. 8, n. 25, 2016. Disponível em: https://link.springer.com/article/10.1186/s13098-016-0126-8. Acesso em: 16 jul. 2026.
Licença:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
URI:	https://ri.ufs.br/jspui/handle/riufs/25578
Aparece nas coleções:	DME - Artigos de periódicos

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