1. Repositório Institucional da Universidade Federal de Sergipe - RI/UFS
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  3. DFS - Departamento de Fisiologia
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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25834
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dc.contributor.authorAndrade, Jacqueline Cosmo-
dc.contributor.authorBraga, Maria Flaviana Bezerra Morais-
dc.contributor.authorGuedes, Glaucia Morgana de Melo-
dc.contributor.authorTintino, Saulo Relison-
dc.contributor.authorFreitas, Maria Audilene de-
dc.contributor.authorQuintans Júnior, Lucindo José-
dc.contributor.authorMenezes, Irwin Rose Alencar de-
dc.contributor.authorCoutinho, Henrique Douglas Melo-
dc.date.accessioned2026-08-20T18:46:53Z-
dc.date.available2026-08-20T18:46:53Z-
dc.date.issued2017-
dc.identifier.citationANDRADE, J. C. et al. Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism. Saudi Journal of Biological Sciences, Amsterdam, v. 24, n. 1, p. 59-64, 2017. DOI: https://doi.org/10.1016/j.sjbs.2015.09.004. Disponível em: https://www.sciencedirect.com/science/article/pii/S1319562X15001990?via%3Dihub. Acesso em: 20 ago. 2026.pt_BR
dc.identifier.issn2213-7106-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25834-
dc.languageengpt_BR
dc.publisherElsevier: King Saud Universitypt_BR
dc.relation.ispartofSaudi Journal of Biological Sciencespt_BR
dc.subjectMenadioneeng
dc.subjectLipid solubilityeng
dc.subjectMicrodilutioneng
dc.subjectAntibiotic-modifyingeng
dc.subjectPermeabilizationeng
dc.titleMenadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanismpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição-Não Comercial-Sem Derivações 4.0 Internacional (CC BY-NC-ND 4.0)pt_BR
dc.description.resumoMenadione, vitamin K3, belongs to the class of lipid-soluble vitamins and lipophilic substances as menadione cause disturbances in the bacterial membrane, resulting in damage to the fundamental elements for the integrity of the membrane, thus allowing increased permeability. Accordingly, the aim of this study was to evaluate in vitro the antibiotic-modifying activity of menadione in multiresistant strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, with a gradual increase in its subinhibitory concentration. In addition, menadione was compared with cholesterol and ergosterol for similarity in mechanism of drug modulatory action. Antibiotic-modifying activity and antibacterial effect were determined by the broth microdilution assay. Menadione, cholesterol and ergosterol showed modulatory activity at clinically relevant concentrations, characterizing them as modifiers of bacterial drug resistance, since they lowered the MIC of the antibiotics tested. This is the first report of the antibacterial activity of menadione and its potentiation of aminoglycosides against multiresistant bacteria.pt_BR
dc.description.localAmsterdampt_BR
dc.identifier.doihttps://doi.org/10.1016/j.sjbs.2015.09.004-
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