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dc.contributor.authorAndrade, Paulo Henrique Santos-
dc.contributor.authorLobo, Iza Maria Fraga-
dc.contributor.authorSilva, Wellington Barros da-
dc.date.accessioned2026-08-20T20:11:56Z-
dc.date.available2026-08-20T20:11:56Z-
dc.date.issued2017-
dc.identifier.citationANDRADE, P. H. S.; LOBO, I. M. F.; SILVA, W. B. Risk factors for adverse drug reactions in pediatric inpatients: a cohort study. PloS One, San Francisco, v. 12, n. 8, 2017. DOI: https://doi.org/10.1371/journal.pone.0182327. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182327. Acesso em: 20 ago. 2026.pt_BR
dc.identifier.issn1932-6203-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25839-
dc.languageengpt_BR
dc.publisherPublic Library of Sciencept_BR
dc.relation.ispartofPloS Onept_BR
dc.subjectAdverse drug reactionseng
dc.subjectChildreneng
dc.subjectCohort studyeng
dc.titleRisk factors for adverse drug reactions in pediatric inpatients: a cohort studypt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoPurpose: The present study aims to identify the risk factors for adverse drug reactions (ADR) in pediatric inpatients. Methods: A prospective cohort study in one general pediatric ward in a hospital in Northeast Brazil was conducted in two stages: the first stage was conducted between August 17th and November 6th, 2015, and the second one between March 1st and August 25th, 2016. We included children aged 0–14 years 11 months hospitalized with a minimum stay of 48 hours. Observed outcomes were the ADR occurrence and the time until the first ADR observed. In the univariate analysis, the time to the first ADR was compared among groups using a logrank test. For the multivariate analysis, the Cox regression model was used. Results: A total of 173 children (208 admissions) and 66 ADR classified as “definite” and “probable” were identified. The incidence rate was 3/100 patient days. The gastro-intestinal system disorders were the main ADR observed (28.8%). In addition, 22.7% of the ADR were related to antibacterials for systemic use and 15.2% to general anesthesia. Prior history of ADR of the child [hazard ratio (HR) 2.44; 95% confidence interval (CI) 1.19–5.00], the use of meglumine antimonate (HR 4.98; 95% CI 1.21–20.54), antibacterial for systemic use (HR 2.75; 95% CI 1.08–6.98) and antiepileptic drugs (HR 3.84; 95% CI 1.40–10.56) were identified risk factors for ADR. Conclusions: We identified as risk factors the prior history of ADR of the child and the use of meglumine antimonate, antibacterial for systemic use and antiepileptic drugspt_BR
dc.description.localSan Franciscopt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0182327-
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