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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25902
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dc.contributor.authorBrandão, Luiz Eduardo Mateus-
dc.contributor.authorNôga, Diana Aline Morais Ferreira-
dc.contributor.authorDierschnabel, Aline Lima-
dc.contributor.authorCampêlo, Clarissa Loureiro das Chagas-
dc.contributor.authorMeurer, Ywlliane da Silva Rodrigues-
dc.contributor.authorLima, Ramón Hypolito-
dc.contributor.authorEngelberth, Rovena Clara Galvão Januário-
dc.contributor.authorCavalcante, Jeferson Souza-
dc.contributor.authorLima, Clésio Andrade-
dc.contributor.authorMarchioro, Murilo-
dc.contributor.authorEstevam, Charles dos Santos-
dc.contributor.authorSantos, José Ronaldo-
dc.contributor.authorSilva, Regina Helena-
dc.contributor.authorRibeiro, Alessandra Mussi-
dc.date.accessioned2026-08-26T20:12:34Z-
dc.date.available2026-08-26T20:12:34Z-
dc.date.issued2017-
dc.identifier.citationBRANDÃO, L. E. M. et al. Passiflora cincinnata extract delays the development of motor signs and prevents dopaminergic loss in a mice model of Parkinson's disease. Evidence-Based Complementary and Alternative Medicine, New York, n. 1, 2017. DOI: https://doi.org/10.1155%2F2017%2F8429290. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2017/8429290. Acesso em: 26 ago. 2026.pt_BR
dc.identifier.issn1741-4288-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25902-
dc.languageengpt_BR
dc.publisherHindawi Publishing Corporationpt_BR
dc.relation.ispartofEvidence-Based Complementary and Alternative Medicinept_BR
dc.subjectParkinson’s diseaseeng
dc.subjectPassiflora cincinnataeng
dc.subjectDopaminergic losseng
dc.subjectMotor signseng
dc.titlePassiflora cincinnata extract delays the development of motor signs and prevents dopaminergic loss in a mice model of Parkinson's diseasept_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoPassiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continentfolk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P.cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects inanimal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on micesubmitted to a progressive model of Parkinson’s disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine(0.1 mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25 mg/kg,i.p.). Catalepsy, open field, oral movements, and plus-maze discriminative avoidance evaluations were performed across treatment,and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayedthe onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However,PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosinehydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine. Taken together, our resultssuggested that PAS exerted a neuroprotective effect in a progressive model of PD.pt_BR
dc.description.localNew Yorkpt_BR
dc.identifier.doihttps://doi.org/10.1155/2017/8429290-
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