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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/25986
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dc.contributor.authorCardoso, Nathalia Nogueira Rodrigues-
dc.contributor.authorAlviano, Celuta Sales-
dc.contributor.authorBlank, Arie Fitzgerald-
dc.contributor.authorArrigoni-Blank, Maria de Fátima-
dc.contributor.authorRomanos, Maria Teresa Villela-
dc.contributor.authorCunha, Marcel Menezes Lyra da-
dc.contributor.authorSilva, Antonio Jorge Ribeiro-
dc.contributor.authorAlviano, Daniela Sales-
dc.date.accessioned2026-09-01T20:01:31Z-
dc.date.available2026-09-01T20:01:31Z-
dc.date.issued2017-
dc.identifier.citationCARDOSO, N. N. R. et al. Anti-cryptococcal activity of ethanol crude extract and hexane fraction fromOcimum basilicum var. Maria bonita: mechanisms of action and synergism withamphotericin B and Ocimum basilicum essential oil. Pharmaceutical Biology, London, v. 55, n. 1, p. 1380–1388, 2017. DOI: https://doi.org/10.1080/13880209.2017.1302483. Disponível em: https://www.tandfonline.com/doi/full/10.1080/13880209.2017.1302483#abstract. Acesso em: 1 set. 2026.pt_BR
dc.identifier.issn1744-5116-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25986-
dc.languageengpt_BR
dc.publisherTaylor & Francispt_BR
dc.relation.ispartofPharmaceutical Biologypt_BR
dc.subjectBasileng
dc.subjectAntifungal activityeng
dc.subjectCryptococcus neoformanseng
dc.subjectDrug synergismeng
dc.subjectErgosteroeng
dc.titleAnti-cryptococcal activity of ethanol crude extract and hexane fraction fromOcimum basilicum var. Maria bonita: mechanisms of action and synergism withamphotericin B and Ocimum basilicum essential oilpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoContext: Ocimum basilicum L. (Lamiaceae) has been used in folk medicine to treat headaches, kidney dis-orders, and intestinal worms.Objective: This study evaluates the anti-cryptococcal activity of ethanol crude extract and hexane fractionobtained from O. basilicum var. Maria Bonita leaves.Materials and methods: The MIC values for Cryptococcus sp. were obtained according to Clinical andLaboratory Standards Institute in a range of 0.3–2500 lg/mL. The checkerboard assay evaluated the associ-ation of the substances tested (in a range of 0.099–2500 lg/mL) with amphotericin B and O. basilicumessential oil for 48 h. The ethanol extract, hexane fraction and associations in a range of 0.3–2500 lg/mLwere tested for pigmentation inhibition after 7 days of treatment. The inhibition of ergosterol synthesisand reduction of capsule size were evaluated after the treatment with ethanol extract (312 lg/mL), hexanefraction (78 lg/mL) and the combinations of essential oil þ ethanol extract (78 lg/mL þ 19.5 lg/mL,respectively) and essential oil þ hexane fraction (39.36 lg/mL þ 10 lg/mL, respectively) for 24 and 48 h,respectively.Results: The hexane fraction presented better results than the ethanol extract, with a low MIC (156 lg/mLagainst C. neoformans T444 and 312 lg/mL against C. neoformans H99 serotype A and C. gattii WM779serotype C). The combination of the ethanol extract and hexane fraction with amphotericin B and essen-tial oil enhanced their antifungal activity, reducing the concentration of each substance needed to kill100% of the inoculum. The substances tested were able to reduce the pigmentation, capsule size andergosterol synthesis, which suggest they have important mechanisms of action.Conclusions: These results provide further support for the use of ethanol extracts of O. basilicum as apotential source of antifungal agents.pt_BR
dc.description.localLondonpt_BR
dc.identifier.doihttp://dx.doi.org/10.1080/13880209.2017.1302483-
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