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dc.contributor.authorCosta, Amanda Fernandes de Oliveira-
dc.contributor.authorMenezes, Daniel Lima-
dc.contributor.authorPinheiro, Lúcio Henrique Sousa-
dc.contributor.authorSandes, Alex Freire-
dc.contributor.authorNunes, Marco Antonio Prado-
dc.contributor.authorLyra Junior, Divaldo Pereira-
dc.contributor.authorSchimieguel, Dulce Marta-
dc.date.accessioned2026-09-09T19:04:58Z-
dc.date.available2026-09-09T19:04:58Z-
dc.date.issued2017-
dc.identifier.citationCOSTA, A. F. O. et al. Role of new immunophenotypic markers on prognostic and overall survival of acute myeloid leukemia: a systematic review and meta-analysis. Scientific reports, London, v. 7, n. 4138, 2017. DOI: https://doi.org/10.1038/s41598-017-00816-2. Disponível em: https://www.nature.com/articles/s41598-017-00816-2. Acesso em: 9 set. 2026.pt_BR
dc.identifier.issn2045-2322-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/26064-
dc.languageengpt_BR
dc.publisherNature Publishing Grouppt_BR
dc.relation.ispartofScientific reportspt_BR
dc.subjectAcute myeloid leukemiaeng
dc.subjectPrognosticeng
dc.subjectImmunophenotypic markerseng
dc.titleRole of new immunophenotypic markers on prognostic and overall survival of acute myeloid leukemia: a systematic review and meta-analysispt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoDespite technological advances, the prognosis and survival of acute myeloid leukemia (AML) adult patients remain low, compared with other hematologic malignancies. Some antigens detected by immunophenotyping may soon play a significant role in the pathophysiologic, prognostic, and overall survival (OS) rate of AML patients. Therefore, we conducted a systematic review and meta-analysis of PubMed, Scopus, Science Direct, Web of Science, and the Cochrane Library (using PRISMA guidelines). We analyzed 11 studies and 13 antigens, detected through the immunophenotyping of 639 patients. From them, twelve exhibited a negative impact with AML prognosis. The meta-analysis demonstrated a high expression of AML markers, which have been associated with a decrease in survival over 10 months (RR 2.55; IC 95%; 1.49–4.37) and over 20 months (RR 2.46; IC 95%; 1.75–3.45). Knowing that the expression of immunophenotypic markers, which are not used on a routine basis, might be able to influence disease behavior, looks promising. However, they have been associated with a poor prognosis as well as a decrease in survival. This may allow for different chemotherapeutical protocols, including future studies for new therapeutic targets.pt_BR
dc.description.localLondonpt_BR
dc.identifier.doihttps://doi.org/10.1038/s41598-017-00816-2-
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