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Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/26113
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dc.contributor.authorOliveira Júnior, Raimundo Gonçalves de-
dc.contributor.authorFerraz, Christiane Adrielly Alves-
dc.contributor.authorSilva, Juliane Cabral-
dc.contributor.authorOliveira, Ana Paula de-
dc.contributor.authorDiniz, Tâmara Coimbra-
dc.contributor.authorSilva, Mariana Gama e-
dc.contributor.authorQuintans Júnior, Lucindo José-
dc.contributor.authorSouza, Ana Valéria Vieira de-
dc.contributor.authorSantos, Uiliane Soares dos-
dc.contributor.authorTuratti, Izabel Cristina Casanova-
dc.contributor.authorLopes, Norberto Peporine-
dc.contributor.authorLorenzo, Vitor Prates-
dc.contributor.authorAlmeida, Jackson Roberto Guedes da Silva-
dc.date.accessioned2026-09-15T20:52:10Z-
dc.date.available2026-09-15T20:52:10Z-
dc.date.issued2017-
dc.identifier.citationOLIVEIRA JÚNIOR, R. G. et al. Antinociceptive effect of the essential oil from Croton conduplicatus Kunth (Euphorbiaceae). Molecules, Basel, v. 22, n. 6, 2017. DOI: https://doi.org/10.3390/molecules22060900. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC6152674/. Acesso em: 15 set. 2026.pt_BR
dc.identifier.issn1420-3049-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/26113-
dc.languageengpt_BR
dc.publisherMDPIpt_BR
dc.relation.ispartofMoleculespt_BR
dc.subjectPaineng
dc.subjectMedicinal plantseng
dc.subjectEssential oileng
dc.subjectTerpenoidseng
dc.titleAntinociceptive effect of the essential oil from Croton conduplicatus Kunth (Euphorbiaceae)pt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoMedicinal plants have been widely used in the treatment of chronic pain. In this study, we describe the antinociceptive effect of the essential oil from Croton conduplicatus (the EO 25, 50, and 100 mg/kg, i.p.), a medicinal plant native to Brazil. Antinociceptive activity was investigated by measuring the nociception induced by acetic acid, formalin, hot plate and carrageenan. A docking study was performed with the major constituents of the EO (E-caryophyllene, caryophyllene oxide, and camphor). The EO reduced nociceptive behavior at all doses tested in the acetic acid-induced nociception test (p < 0.05). The same was observed in both phases (neurogenic and inflammatory) of the formalin test. When the hot-plate test was conducted, the EO (50 mg/kg) extended the latency time after 60 min of treatment. The EO also reduced leukocyte migration at all doses, suggesting that its antinociceptive effect involves both central and peripheral mechanisms. Pretreatment with glibenclamide and atropine reversed the antinociceptive effect of the EO on the formalin test, suggesting the involvement of KATP channels and muscarinic receptors. The docking study revealed a satisfactory interaction profile between the major components of the EO and the different muscarinic receptor subtypes (M2, M3, and M4). These results corroborate the medicinal use of C. conduplicatus in folk medicine.pt_BR
dc.description.localBaselpt_BR
dc.identifier.doihttps://doi.org/10.3390/molecules22060900-
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