Please use this identifier to cite or link to this item: http://ri.ufs.br/jspui/handle/riufs/613
Document Type: Artigo
Title: Assessment of antinociceptive and anti-inflammatory activities of Porophyllum ruderale (Jacq.) Cass., Asteraceae, aqueous extract
Authors: Lima, Gabrielle Mendes
Bonfim, Rangel Rodrigues
Silva, Mônica Rodrigues da
Thomazzi, Sara Maria
Santos, Márcio Roberto Viana dos
Quintans-Júnior, Lucindo José
Bonjardim, Leonardo Rigoldi
Araújo, Adriano Antunes de Souza
Issue Date: Jun-2011
Abstract: The present work investigated the antinociceptive and antiinflammatory activities of the Porophyllum ruderale (Jacq.) Cass., Asteraceae, aqueous extract (PRAE). For this purpose, acetic acid writhing, paw licking induced by formalin, hot-plate and pleurisy tests were performed. The doses of 100, 200 and 400 mg/kg (p.o.) significantly inhibited the writhing 63.4, 89.6 and 94.8%, respectively, in comparison with control group. The lick of the paw 1st phase was reduced at the dose of 400 mg/ kg (24.9%), while the 2nd phase had reduction at doses 200 and 400 mg/ kg (23.1 and 34.4%), respectively. The PRAE inhibited the carrageenaninduced neutrophil migration to the peritoneal cavity in a higher dose (p<0.05). Taken together, our results suggest that the PRAE can constitute target potential for use in therapies of the pain and inflammation.
Keywords: Asteraceae
Porophyllum ruderale
Atividade antinociceptiva
Anti-inflamatório
Plantas medicinais
ISSN: 0102-695X
Citation: LIMA, G. M. et al. Assessment of antinociceptive and anti-inflammatory activities of Porophyllum ruderale (Jacq.) Cass., Asteraceae, aqueous extract. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 3, p. 486-490, jun. 2011. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300021&lng=en&nrm=iso>. Acesso em: 11 jun. 2013.
License: Creative Commons Attribution License
URI: https://ri.ufs.br/handle/riufs/613
Appears in Collections:DFA - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
AssessmentPorophyllumRuderale.pdf728,34 kBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.