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Document Type: Artigo
Title: Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing
Authors: Nunes, Paula Santos
Albuquerque Júnior, Ricardo Luiz Cavalcanti de
Cavalcante, Danielle Rodrigues Ribeiro
Dantas, Marx Diego Meneses
Cardoso, Juliana Cordeiro
Bezerra, Marília dos Santos
Souza, Jamille Cristina Campos de
Serafini, Mairim Russo
Quintans-Júnior, Lucindo José
Bonjardim, Leonardo Rigoldi
Araújo, Adriano Antunes de Souza
Issue Date: 2011
Abstract: The aim of this study was assess the effect of collagen-based films containing usnic acid as a wound dressing for dermal burn healing. Second-degree burn wounds were performed in forty-five Wistar rats, assigned into nine groups: COL—animals treated with collagen-based films; PHO—animals treated with collagen films containing empty liposomes; UAL—animals treated with collagen-based films containing usnic acid incorporated into liposomes. After 7, 14, and 21 days the animals were euthanized. On 7th day there was a moderate infiltration of neutrophils, in UAL, distributed throughout the burn wounds, whereas in COL and PHO, the severity of the reaction was slighter and still limited to the margins of the burn wounds. On the 14th day, the inflammatory reaction was less intense in UAL, with remarkable plasma cells infiltration. On the 21st day, there was reduction of the inflammation, which was predominantly composed of plasma cells in all groups, particularly in UAL. The use of the usnic acid provided more rapid substitution of type-III for type-I collagen on the 14th day, and improved the collagenization density on the 21st day. It was concluded that the use of reconstituted bovine type-I collagen-based films containing usnic acid improved burn healing process in rats
Keywords: Filmes de colágeno
Ácido úsnico
ISSN: 1110-7251
Publisher / Institution : Hindawi
Citation: NUNES, Paula S. et al. Collagen-based films containing liposome-loaded usnic acid as dressing for dermal burn healing. Journal of Biomedicine and Biotechnology, v. 2011, 2011. Disponível em: <>. Acesso em: 21 jun. 2013
License: Creative Commons Attribution License
Appears in Collections:DFA - Artigos de periódicos

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