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Document Type: Artigo
Title: Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models
Authors: Quintans-Júnior, Lucindo José
Moreira, José Cláudio Fonseca
Pasquali, Matheus Augusto De Bittencourt
Rabie, Soheyla Mohd
Pires, André Simões
Schroder, Rafael
Rabelo, Thallita Kelly
Santos, João Paulo Almeida dos
Lima, Pollyana Souza
Cavalcanti, Sócrates Cabral de Holanda
Araújo, Adriano Antunes de Souza
Quintans, Jullyana de Souza Siqueira
Gelain, Daniel Pens
Issue Date: 2013
Abstract: Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate.
Keywords: Atividade antinociceptiva
Acetato de geranilo
ISSN: 2090-6196
Publisher / Institution : Hindawi
Citation: QUINTANS-JÚNIOR, L.J. et al. Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models. ISRN Toxicology, Cairo, v. 2013, 2013. Disponível em: <>. Acesso em: 21 jun. 2013.
License: Creative Commons Attribution License
Appears in Collections:DFA - Artigos publicados em periódicos

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