Please use this identifier to cite or link to this item:
https://ri.ufs.br/jspui/handle/riufs/619
Document Type: | Artigo |
Title: | Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models |
Authors: | Quintans-Júnior, Lucindo José Moreira, José Cláudio Fonseca Pasquali, Matheus Augusto De Bittencourt Rabie, Soheyla Mohd Pires, André Simões Schroder, Rafael Rabelo, Thallita Kelly Santos, João Paulo Almeida dos Lima, Pollyana Souza Cavalcanti, Sócrates Cabral de Holanda Araújo, Adriano Antunes de Souza Quintans, Jullyana de Souza Siqueira Gelain, Daniel Pens |
Issue Date: | 2013 |
Abstract: | Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate. |
Keywords: | Atividade antinociceptiva Monoterpenos p-Cimeno Acetato de geranilo |
ISSN: | 2090-6196 |
Publisher / Institution : | Hindawi |
Citation: | QUINTANS-JÚNIOR, L.J. et al. Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models. ISRN Toxicology, Cairo, v. 2013, 2013. Disponível em: <http://www.hindawi.com/isrn/toxicology/2013/459530/abs/>. Acesso em: 21 jun. 2013. |
License: | Creative Commons Attribution License |
URI: | http://www.hindawi.com/isrn/toxicology/2013/459530/abs/ https://ri.ufs.br/handle/riufs/619 |
Appears in Collections: | DFA - Artigos de periódicos |
Files in This Item:
File | Description | Size | Format | |
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AntinociceptiveActivityMonoterpenes.pdf | 1,59 MB | Adobe PDF | ![]() View/Open |
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