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Document Type: Artigo
Title: Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass
Authors: Quintans-Júnior, Lucindo José
Rocha, Ricardo Fagundes da
Caregnato, Fernanda Freitas
Moreira, José Cláudio Fonseca
Silva, Francilene Amaral da
Araújo, Adriano Antunes de Souza
Santos, João Paulo Almeida dos
Melo, Mônica Santos de
Sousa, Damião Pergentino de
Bonjardim, Leonardo Rigoldi
Gelain, Daniel Pens
Issue Date: May-2011
Abstract: Citronellal (CT) is a monoterpenoid and the major constituent of the mixture of terpenoids that give the citronella oil its lemon scent. Citronella oil is widely used around the world for various purposes and is mainly obtained from plants of the Cymbopogon genus, which are known as “lemongrass.” Considering these plants have been used worldwide for various medicinal purposes, the interest of researchers to understand the biological activities of monoterpenoids related to the Cymbopogon genus has been increasing. In the present work, we investigated the antinociceptive action and the redox properties of CT. Our results indicate that intraperitoneal injection of CT was effective in reducing nociceptive face-rubbing behavior in both phases of the formalin test, which was also naloxone-sensitive. CT also evoked antinociceptive response in the capsaicin and glutamate tests. The total radical-trapping antioxidant parameter and total antioxidant reactivity assays indicate that CT at doses of 0.1 and 1 mg/mL exerts a significant antioxidant activity, which is probably related to its ability to scavenge superoxide and nitric oxide, but not H2O2 or hydroxyl radicals, as evaluated separately by specific in vitro tests. These results show for the first time the antinociceptive potential of CT and indicate that the antioxidant properties of this compound may rely on its mechanism of biological actions because CT-containing natural products are used to treat various diseases related to oxidative stress and reactive species.
Keywords: Atividade antinociceptiva
Propriedades redox
Óleos essenciais
ISSN: 1557-7600
Publisher / Institution : Mary Ann Liebert, Inc.
Citation: QUINTANS-JÚNIOR, L. J. et al. Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass. Journal of Medicinal Food, San Diego, v. 14, n. 6, p. 630-639, maio 2011. Disponível em: <>. Acesso em: 21 jun. 2013.
License: Mary Ann Liebert, Inc.
Appears in Collections:DFA - Artigos publicados em periódicos

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