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https://ri.ufs.br/jspui/handle/riufs/622
Tipo de Documento: | Artigo |
Título : | Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach |
Autor : | Quintans-Júnior, Lucindo José Silva, Davi Antas Quintans, Jullyana de Souza Siqueira Araújo, Adriano Antunes de Souza Siqueira, Rosana de Souza Bonjardim, Leonardo Rigoldi Santana, Josimari Melo de Lucca Júnior, Waldecy de Souza, Maria Fátima Vanderlei Gutierrez, Stanley Juan Chavez Barbosa Filho, José Maria Santana Filho, Valter Araújo, Demetrius Antonio Machado de Almeida, Reinaldo Nobrega de |
Fecha de publicación : | 2010 |
Resumen : | We investigated the antinociceptive and nerve excitability effects of the N-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5 mg/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p.) to mice in the first and second phases of the formalin test. Because the antinociceptive effects could be associated with neuronal excitability inhibition, we performed the single sucrose gap technique and showed that NST (3.57 mM) significantly reduced (29.2%) amplitude of the compound action potential (CAP) suggesting a sodium channel effect induced by NST. Our results demonstrated an antinociceptive activity of the NST that could be, at least in part, associated to the reduction of the action potential amplitude. NST might represent an important tool for pain management. |
Palabras clave : | Avaliação biomonitorada Atividade antinociceptiva N-saliciloiltriptamina |
ISSN : | 2314-6141 |
Institución / Editorial : | Hindawi |
Citación : | QUINTANS-JÚNIOR, L. J. et al. Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach. Journal of Biomedicine and Biotechnology, Cairo, v. 2010, 2010. Disponível em: <http://www.hindawi.com/journals/bmri/2010/230745/>. Acesso em: 25 jun. 2013. |
License: | Creative Commons Attribution License |
URI : | https://ri.ufs.br/handle/riufs/622 |
Aparece en las colecciones: | DFA - Artigos de periódicos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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BioassayNSalicyloltryptamine.pdf | 1,35 MB | Adobe PDF | ![]() Visualizar/Abrir |
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