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Document Type: Artigo
Title: Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach
Authors: Quintans-Júnior, Lucindo José
Silva, Davi Antas
Quintans, Jullyana de Souza Siqueira
Araújo, Adriano Antunes de Souza
Siqueira, Rosana de Souza
Bonjardim, Leonardo Rigoldi
Santana, Josimari Melo de
Lucca Júnior, Waldecy de
Souza, Maria Fátima Vanderlei
Gutierrez, Stanley Juan Chavez
Barbosa Filho, José Maria
Santana Filho, Valter
Araújo, Demetrius Antonio Machado de
Almeida, Reinaldo Nobrega de
Issue Date: 2010
Abstract: We investigated the antinociceptive and nerve excitability effects of the N-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5 mg/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p.) to mice in the first and second phases of the formalin test. Because the antinociceptive effects could be associated with neuronal excitability inhibition, we performed the single sucrose gap technique and showed that NST (3.57 mM) significantly reduced (29.2%) amplitude of the compound action potential (CAP) suggesting a sodium channel effect induced by NST. Our results demonstrated an antinociceptive activity of the NST that could be, at least in part, associated to the reduction of the action potential amplitude. NST might represent an important tool for pain management.
Keywords: Avaliação biomonitorada
Atividade antinociceptiva
ISSN: 2314-6141
Publisher / Institution : Hindawi
Citation: QUINTANS-JÚNIOR, L. J. et al. Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach. Journal of Biomedicine and Biotechnology, Cairo, v. 2010, 2010. Disponível em: <>. Acesso em: 25 jun. 2013.
License: Creative Commons Attribution License
Appears in Collections:DFA - Artigos publicados em periódicos

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