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Document Type: Artigo
Title: Pre-clinical toxicity of Morinda citrifolia Linn. leaf extract
Authors: Serafini, Mairim Russo
Santos, Rodrigo Correia
Dória, Grace Anne Azevedo
Jesus, Josepha Yohanna de
Melo, Marcelia Garcez Dória de
Santos, João Paulo Almeida dos
Rabelo, Thallita Kelly
Fortes, Vanessa Silveira
Fonseca, Maria José Vieira
Albuquerque Júnior, Ricardo Luiz Cavalcanti de
Quintans-Júnior, Lucindo José
Araújo, Adriano Antunes de Souza
Issue Date: Oct-2011
Abstract: This investigation was carried out to evaluate the safety of an aqueous extract of Morinda citrifolia leaves (AEMC) by determining its potential toxicity after acute administration (5 g/kg) in rodents and cytotoxic studies. General behavior adverse effects and mortality were determined for up to 14 days. Biochemical and hematological parameters were determined after 14 days. Cytotoxic effects of the AEMC were determined by spectrophotometric 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay (at concentration of 0.05 to 25 mg/ml). The results showed that in the acute study in rats, the AEMC did not cause general behavior adverse effects and mortality. Also, AEMC did not show any cytotoxic effect at 0.05 to 12.5 mg/ml, only at 25 mg/ml. The AEMC does not appear to have significant toxicity.
Keywords: Morinda citrifolia
Toxicidade aguda
ISSN: 1684–5315
Publisher / Institution : Academic Journals
Citation: SERAFINI, M. R. et al. Pre-clinical toxicity of Morinda citrifolia Linn. leaf extract. African Journal of Biotechnology, Nairobi, v. 10, n. 65, p. 14566-14572, out. 2011. Disponível em: <>. Acesso em: 25 jun. 2013
License: Creative Commons Attribution License
Appears in Collections:DFA - Artigos publicados em periódicos

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