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https://ri.ufs.br/jspui/handle/riufs/7314| Document Type: | Artigo |
| Title: | Preparation, characterization, and pharmacological activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) leaf essential oil of B-cyclodextrin inclusion complexes |
| Authors: | Santos, Priscila Laíse dos Araujo, Adriano Antunes de Souza Quintans, Jullyana de Souza Siqueira Brito, Renan Guedes de Serafini, Mairim Russo Menezes, Paula dos Passos Santos, Márcio Roberto Viana dos Alves, Péricles Barreto Lucca Júnior, Waldecy de Blank, Arie Fitzgerald La Rocca, Viviana Almeida, Reinaldo Nobrega de Quintans Júnior, Lucindo José |
| Issue Date: | 2015 |
| Resumo : | This study aimed to evaluate the orofacial antinociceptive effect of the Cymbopogon winterianus essential oil (LEO) complexed in B-cyclodextrin (LEO-CD) and to assess the possible involvement of the central nervous system (CNS). The LEO was extracted, chromatographed, and complexed in B-cyclodextrin. The complex was characterized by differential scanning calorimetry (DSC) and thermogravimetry derivative (TG/DTG). Male Swiss mice (2-3 months) were treated with LEO-CD (50–200 mg/kg, p.o.), vehicle (distilled water, p.o.), or standard drug (i.p.) and subjected to the orofacial nociception formalin-, capsaicin-, and glutamateinduced. After the formalin test, the animals were perfused and the brains subjected to immunofluorescence for Fos. The rota-rod test (7 rpm/min) was carried out. Geraniol (37.57%) was the main compound of LEO. DSC and TG/DTG proved the complexation. The orofacial nociceptive behavior was significantly (p < 0.05) reduced. The number of Fos-positive cells was significantly changed in the dorsal raphe nucleus (p < 0.01), locus coeruleus (p < 0.001), trigeminal nucleus (p < 0.05), and trigeminal thalamic tract (p < 0.05). LEO-CD did not cause changes in motor coordination in the rota-rod test. Thus, our results suggested that LEO-CD has an orofacial antinociceptive profile, probably mediated by the activation of the CNS without changing the motor coordination. |
| Keywords: | Cymbopogon winterianus Essential oils β-cyclodextrin Óleos essenciais β-ciclodextrina |
| ISSN: | 1741-427X |
| Is part of: | Evidence-Based Complementary and Alternative Medicine |
| Language: | eng |
| Publisher / Institution : | Hindawi Publishing Corporation |
| Citation: | SANTOS, P. L. dos et al. Preparation, characterization, and pharmacological activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) leaf essential oil of B-cyclodextrin inclusion complexes. Evidence-Based Complementary and Alternative Medicine, v. 2015, 2015. Disponível em: <https://www.hindawi.com/journals/ecam/2015/502454/>. Acesso em: 05 fev. 2018. |
| License: | Creative Commons Atribuição-Sem Derivações-Sem Derivados 3.0 Não Adaptada (CC BY-NC-ND 3.0) |
| URI: | http://ri.ufs.br/jspui/handle/riufs/7314 |
| Appears in Collections: | DEA - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| CymbopogonWinterianusLeafEssentialOil.pdf | 5,97 MB | Adobe PDF |  View/Open |
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