Use este identificador para citar ou linkar para este item: http://ri.ufs.br/jspui/handle/riufs/7314
Tipo de Documento: Artigo
Título: Preparation, characterization, and pharmacological activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) leaf essential oil of B-cyclodextrin inclusion complexes
Autor(es): Santos, Priscila Laíse dos
Araujo, Adriano Antunes de Souza
Quintans, Jullyana de Souza Siqueira
Brito, Renan Guedes de
Serafini, Mairim Russo
Menezes, Paula dos Passos
Santos, Márcio Roberto Viana dos
Alves, Péricles Barreto
Lucca Junior, Waldecy de
Blank, Arie Fitzgerald
La Rocca, Viviana
Almeida, Reinaldo Nobrega de
Quintans Júnior, Lucindo José
Data do documento: 2015
Resumo: This study aimed to evaluate the orofacial antinociceptive effect of the Cymbopogon winterianus essential oil (LEO) complexed in B-cyclodextrin (LEO-CD) and to assess the possible involvement of the central nervous system (CNS). The LEO was extracted, chromatographed, and complexed in B-cyclodextrin. The complex was characterized by differential scanning calorimetry (DSC) and thermogravimetry derivative (TG/DTG). Male Swiss mice (2-3 months) were treated with LEO-CD (50–200 mg/kg, p.o.), vehicle (distilled water, p.o.), or standard drug (i.p.) and subjected to the orofacial nociception formalin-, capsaicin-, and glutamateinduced. After the formalin test, the animals were perfused and the brains subjected to immunofluorescence for Fos. The rota-rod test (7 rpm/min) was carried out. Geraniol (37.57%) was the main compound of LEO. DSC and TG/DTG proved the complexation. The orofacial nociceptive behavior was significantly (p < 0.05) reduced. The number of Fos-positive cells was significantly changed in the dorsal raphe nucleus (p < 0.01), locus coeruleus (p < 0.001), trigeminal nucleus (p < 0.05), and trigeminal thalamic tract (p < 0.05). LEO-CD did not cause changes in motor coordination in the rota-rod test. Thus, our results suggested that LEO-CD has an orofacial antinociceptive profile, probably mediated by the activation of the CNS without changing the motor coordination.
Palavras-chave: Cymbopogon winterianus
Essential oils
β-cyclodextrin
Óleos essenciais
β-ciclodextrina
ISSN: 1741-427X
Parte de : Evidence-Based Complementary and Alternative Medicine
Idioma: eng
Instituição/Editora: Hindawi Publishing Corporation
Citação: SANTOS, P. L. dos et al. Preparation, characterization, and pharmacological activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) leaf essential oil of B-cyclodextrin inclusion complexes. Evidence-Based Complementary and Alternative Medicine, v. 2015, 2015. Disponível em: <https://www.hindawi.com/journals/ecam/2015/502454/>. Acesso em: 05 fev. 2018.
Licença: Creative Commons Atribuição-Sem Derivações-Sem Derivados 3.0 Não Adaptada (CC BY-NC-ND 3.0)
URI: http://ri.ufs.br/jspui/handle/riufs/7314
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