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Document Type: Artigo
Title: Transfusional iron overload in patients with sickle cell anemia: comparison between magnetic resonance imaging and serum ferritin
Authors: Bourbon Filho, Lécio dos Anjos
Ferrão, Thiago de Oliveira
França, Alex Vianey Callado
Rocha, Ricardo Dantas
Dantas, Lorena Dias
Carvalho, Luciana Franco do Prado
Moreira, Marcella Dornelas de Abreu Batalha
Cipolotti, Rosana
Issue Date: Jun-2011
Abstract: OBJECTIVE: To identify predictive variables of iron overload in patients with sickle cell anemia, correlating biochemical and imaging markers. MATERIALS AND METHODS: The authors developed a cross-sectional study involving 32 patients with sickle cell anemia who were evaluated for ferritin and iron serum levels and submitted to liver magnetic resonance imaging with one spin-echo and five gradient-echo sequences. The signal intensity was obtained at each sequence, corresponding to the arithmetical mean of the measurements on regions of interest in the liver and paraspinal muscles to obtain the liver/muscle signal intensity ratio (SIR). Based on such SIR, the liver iron concentration (LIC) was estimated by means of the following formula: e[5.808 - (0.877 × T2*) - (1.518 × IW)], where T2* is the SIR on the sequence with echo time = 13 ms and IW is the SIR on the intermediate-weighted sequence. Patients were grouped according to their blood transfusion regimen (regular monthly versus sporadic transfusions). RESULTS: The comparison between the transfusion groups was based on clinical-laboratory variables, with significant differences in SIR, LIC and serum ferritin levels: the group with regular transfusions demonstrated greater hepatic iron overload. CONCLUSION: Magnetic resonance imaging is an efficient tool for evaluating liver iron overload in patients with sickle cell anemia.
Keywords: Anemia falciforme
Ressonância magnética
Ferro transfusional
Ferritina sérica
ISSN: 0100-3984
Publisher / Institution : Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
Citation: BOURBON FILHO, L. A. et al. Sobrecarga de ferro transfusional em portadores de anemia falciforme: comparação entre ressonância magnética e ferritina sérica. Radiologia Brasileira, São Paulo, v. 44, n. 3, maio/jun. 2011. Disponível em: <>. Acesso em: 13 nov. 2013.
License: Creative Commons Attribution License
Appears in Collections:DME - Artigos publicados em periódicos

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