Use este identificador para citar ou linkar para este item: http://ri.ufs.br/jspui/handle/riufs/807
Tipo de Documento: Artigo
Título: Prevalence, genotypes and factors associated with HCV infection among prisoners in Northeastern Brazil
Autor(es): Santos, Bruno Fernandes de Oliveira
Santana, Nathalie Oliveira de
França, Alex Vianey Callado
Data do documento: Jul-2011
Abstract: AIM: To determine hepatitis C virus (HCV) seroprevalence and its genotypes, and to identify the factors associated with HCV infection. METHODS: This cross-sectional study, conducted in two prisons (one male and one female) in the State of Sergipe, Brazil, comprised 422 subjects. All of the prisoners underwent a rapid test for the detection of HCV antibodies. Patients with a positive result were tested for anti-HCV by enzyme linked immunosorbent assay and for HCV RNA by qualitative polymerase chain reaction (PCR). The virus genotype was defined in every serum sample that presented positive for PCR-HCV. In order to determine the factors independently associated with positive serology for HCV, multivariate logistic regression was used. RESULTS: HCV seroprevalence was 3.1%. Of the 13 subjects with positive anti-HCV, 11 had viremia confirmed by PCR. Of these, 90.9% had genotype 1. A total of 43 (10.2%) were injecting drug users, and HCV seroprevalence in this subgroup was 20.6%. The variable most strongly associated with positive serology for HCV was use of injecting drugs [odds ratio (OR), 23.3; 95% confidence interval (CI), 6.0-90.8]. Age over 30 years (OR, 5.5; 95%CI, 1.1-29.2), history of syphilis (OR, 9.8; 95%CI, 1.7-55.2) and history of household contact with HCV positive individual (OR, 14.1; 95%CI, 2.3-85.4) were also independently associated with HCV infection. CONCLUSION: Most of the HCV transmissions result from parenteral exposure. However, there is evidence to suggest a role for sex and household contact with an infected subject in virus transmission.
Palavras-chave: Hepatite C
Prisioneiros
Detentos
Usuários de drogas
ISSN: 2219-2840
Instituição/Editora: Baishideng Publishing Group Co.
Citação: SANTOS B. F. O.; SANTANA, N. O. ; FRANÇA, A. v. c. Prevalence, genotypes and factors associated with HCV infection among prisoners in Northeastern Brazil. World Journal of Gastroenterology, Hong Kong, v. 17, n. 25, p. 3027-3034, jul. 2011. Disponível em: <http://www.wjgnet.com/1007-9327/full/v17/i25/3027.htm>. Acesso em: 14 nov. 2013.
Licença: Copyright©2011 Baishideng Publishing Group Co., Limited. All rights reserved
URI: https://ri.ufs.br/handle/riufs/807
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