Avaliação longitudinal do perfil lipídico em pacientes com leishmaniose visceral

Abstract

INTRODUCTION: Visceral Leishmaniasis is an endemic disease in Brazil. Although the lipid profile alteration occurs in Visceral Leishmaniasis, there are few studies evaluating this change and your pathophysiology. The objective is to observe the behavior of the lipid profile before and after treatment of patients with visceral leishmaniasis admitted in a reference service. METHODS: Longitudinal study, descriptive of 13 patients, six adults and seven children diagnosed with Leishmaniasis, which determined the plasma concentration of total cholesterol, high density lipoprotein, low density lipoprotein and triglycerides in three different times: before treatment (T0), immediately after treatment (T1) and 30 days after the end of treatment (T2). Also it were analyzed: age, weight, height and body mass index. RESULTS: T0 were observed elevated triglycerides and low levels of total cholesterol, low density lipoprotein and high density lipoprotein. All patients showed values of high density lipoprotein below 30 mg/dL. Only one patient had triglyceride levels below 150 mg / dL. And following, at times T1 and T2, was evidenced for a significant increase in levels of total cholesterol (p = 0.03), high density lipoprotein (p = 0.001) and low density lipoprotein (0.02) and a reduction significant amount of triglycerides (p = 0.002). CONCLUSION: Visceral leishmaniasis is associated with changes in plasma levels of total cholesterol, triglycerides and lipoproteins, characterized by hypocholesterolemia and hypertriglyceridemia. These alterations showed reversibility with specific therapy for visceral leishmaniasis.