Use este identificador para citar ou linkar para este item: http://ri.ufs.br/jspui/handle/riufs/917
Tipo de Documento: Artigo
Título: Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis
Autor(es): Faria, Daniela Rodrigues de
Gollob, Kenneth John
Barbosa Júnior, José
Schriefer, Nicolaus Albert Borges
Machado, Paulo Roberto Lima
Lessa, Hélio
Carvalho, Lucas Pedreira de
Silva, Marco Aurelio Romano
Jesus, Amélia Maria Ribeiro de
Carvalho Filho, Edgar Marcelino de
Dutra, Walderez Ornelas
Data do documento: Dez-2005
Abstract: Human infection with Leishmania braziliensis can lead to cutaneous leishmaniasis (CL) or mucosal leishmaniasis (ML). We hypothesize that the intense tissue destruction observed in ML is a consequence of an uncontrolled exacerbated inflammatory immune response, with cytotoxic activity. For the first time, this work identifies the cellular sources of inflammatory and antiinflammatory cytokines, the expression of effector molecules, and the expression of interleukin-10 (IL-10) receptor in ML and CL lesions by using confocal microscopy. ML lesions displayed a higher number of gamma interferon (IFN-γ)-producing cells than did CL lesions. In both ML and CL, CD4+ cells represented the majority of IFN-γ-producing cells, followed by CD8+ cells and CD4− CD8− cells. The numbers of tumor necrosis factor alpha-positive cells, as well as those of IL-10-producing cells, were similar in ML and CL lesions. The effector molecule granzyme A showed greater expression in ML than in CL lesions, while inducible nitric oxide synthase did not. Finally, the expression of IL-10 receptor was lower in ML than in CL lesions. Thus, our data identified distinct cytokine and cell population profiles for CL versus ML patients and provide a possible mechanism for the development of ML disease through the demonstration that low expression of IL-10 receptor is present in conjunction with a cytotoxic and inflammatory profile in ML.
Palavras-chave: Leishmaniose cutânea
Leishmaniose mucosa
Interleucina
Interleucina 10
ISSN: 1098-5522
Instituição/Editora: American Society for Microbiology
Citação: FARIA, D. R et al. Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis. Infection and Immunity, Washington, v. 73, n. 12, dez. 2005. Disponível em: <http://iai.asm.org/content/73/12/7853.full>. Acesso em: 19 fev. 2014.
Licença: Copyright © by the American Society for Microbiology
URI: https://ri.ufs.br/handle/riufs/917
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