Use este identificador para citar ou linkar para este item:
https://ri.ufs.br/jspui/handle/riufs/918
Tipo de Documento: | Artigo |
Título: | Up-regulation of Th1-type responses in mucosal leishmaniasis patients |
Autor(es): | Bacellar, Olívia Lessa, Hélio Schriefer, Albert Machado, Paulo Roberto Lima Jesus, Amélia Maria Ribeiro de Dutra, Walderez Ornelas Gollob, Kenneth John Carvalho Filho, Edgar Marcelino de |
Data do documento: | Dez-2002 |
Abstract: | The cytokine profile produced by peripheral blood mononuclear cells (PBMC) in response to leishmania antigens and the ability of interleukin-10 (IL-10) and transforming growth factor β (TGF-β) to modulate the immune response were evaluated in 21 mucosal leishmaniasis patients. Patients with mucosal disease exhibited increased gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α) secretion and decreased IL-10 secretion compared to patients with classical cutaneous leishmaniasis. CD4+ Th1 cells were the main source of IFN-γ and TNF-α production in mucosal leishmaniasis patients. Evaluation of cytokine gene expression in PBMC of these patients showed that there was strong up-regulation of IFN-γ transcripts upon stimulation with leishmania antigen, in contrast to the baseline levels of IL-10 mRNA. IL-10 suppressed IFN-γ production by 48% in cell cultures from cutaneous leishmaniasis patients and by 86% in cell cultures from healthy subjects stimulated with purified protein derivative, whereas in similar conditions IL-10 suppressed IFN-γ production by 19% in cell cultures from mucosal leishmaniasis patients stimulated with leishmania antigen. TGF-β suppressed IFN-γ levels to a greater extent in healthy subjects than in mucosal leishmaniasis and cutaneous leishmaniasis patients. These data indicate that a poorly modulated T-cell response in mucosal leishmaniasis patients leads to production of high levels of proinflammatory cytokines, such as IFN-γ and TNF-α, as well as a decreased ability of IL-10 and TGF-β to modulate this response. These abnormalities may be the basis for the pathological findings observed in this disease. |
Palavras-chave: | Leishmaniose mucosa Citocinas Interleucina Interleucina 10 |
ISSN: | 1098-5522 |
Instituição/Editora: | American Society for Microbiology |
Citação: | BACELLAR, O et al. Up-regulation of Th1-type responses in mucosal leishmaniasis patients. Infection and Immunity, Washington, v. 70, n. 12, dez. 2002. Disponível em: <http://iai.asm.org/content/70/12/6734.long>. Acesso em: 19 fev. 2014. |
Licença: | Copyright © by the American Society for Microbiology |
URI: | https://ri.ufs.br/handle/riufs/918 |
Aparece nas coleções: | DME - Artigos de periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
UpRegulationTh1.pdf | 198,85 kB | Adobe PDF | ![]() Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.