Use este identificador para citar ou linkar para este item: http://ri.ufs.br/jspui/handle/riufs/922
Tipo de Documento: Artigo
Título: Identification of immunodominant epitopes of Schistosoma mansoni vaccine candidate antigens using human T cells
Autor(es): Fonseca, Cristina Toscano
Cunha Neto, Edécio
Kalil, Jorge
Jesus, Amélia Maria Ribeiro de
Oliveira, Rodrigo Correa
Carvalho Filho, Edgar Marcelino de
Oliveira, Sérgio Costa
Data do documento: Ago-2004
Abstract: Paramyosin and Sm14 are two of the six antigens selected by the World Health Organization as candidates to compose a subunit vaccine against schistosomiasis. Both antigens are recognized by individuals naturally resistant to Schistosoma mansoni infection and induced protective immunity in the murine model. Three Sm14 epitopes and eleven paramyosin epitopes were selected by their ability to bind to different HLA-DR molecules using the TEPITOPE computer program, and these peptides were synthetically produced. The cellular recognition of Sm14 and paramyosin epitopes by peripheral blood mononuclear cells of individuals living in endemic area for schistosomiasis was tested by T cell proliferation assay. Among all Sm14 and paramyosin epitopes studied, Sm14-3 was preferentially recognized by individuals naturally resistant to S. mansoni infection while Para-5 was preferentially recognized by individuals resistant to reinfection. These two peptides represent promising antigens to be used in an experimental vaccine against schistosomiasis, since their preferential recognition by resistant individuals suggest their involvement in the induction of protective immunity.
Palavras-chave: Esquistossomo
Schistosoma mansoni
Esquistossomose
Antígenos
Linfócito T
Peptídeos sintéticos
Paramiosina
ISSN: 0074-0276
Instituição/Editora: Fundação Oswaldo Cruz
Citação: FONSECA, C. T. et al. Identification of immunodominant epitopes of Schistosoma mansoni vaccine candidate antigens using human T cells. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, supl. 1, ago. 2004. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900011&lng=en&nrm=iso&tlng=en>. Acesso em: 19 fev. 2014.
Licença: Creative Commons Attribution License
URI: https://ri.ufs.br/handle/riufs/922
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