Use este identificador para citar ou linkar para este item: http://ri.ufs.br/jspui/handle/riufs/924
Tipo de Documento: Artigo
Título: Cytokine profile and pathology in human leishmaniasis
Autor(es): Jesus, Amélia Maria Ribeiro de
Almeida, Roque Pacheco de
Lessa, Hélio
Bacellar, Olívia
Carvalho Filho, Edgar Marcelino de
Data do documento: Jan-1998
Abstract: The clinical spectrum of leishmaniasis and control of the infection are influenced by the parasite-host relationship. The role of cellular immune responses of the Th1 type in the protection against disease in experimental and human leishmaniasis is well established. In humans, production of IFN-g is associated with the control of infection in children infected by Leishmania chagasi. In visceral leishmaniasis, an impairment in IFN-g production and high IL-4 and IL-10 levels (Th2 cytokines) are observed in antigen-stimulated peripheral blood mononuclear cells (PBMC). Moreover, IL-12 restores IFN-g production and enhances the cytotoxic response. IL-10 is the cytokine involved in down-regulation of IFN-g production, since anti-IL-10 monoclonal antibody (mAb) restores in vitro IFN-g production and lymphoproliferative responses, and IL-10 abrogates the effect of IL-12. In cutaneous and mucosal leishmaniasis, high levels of IFN-g are found in L. amazonensis-stimulated PBMC. However, low or absent IFN-g levels were observed in antigen-stimulated PBMC from 50% of subjects with less than 60 days of disease (24 ± 26 pg/ml). This response was restored by IL-12 (308 ± 342 pg/ml) and anti-IL-10 mAb (380 ± 245 pg/ml) (P<0.05). Later during the disease, high levels of IFN-g and TNF-a are produced both in cutaneous and mucosal leishmaniasis. After treatment there is a decrease in TNF-a levels (366 ± 224 pg/ml before treatment vs 142 ± 107 pg/ml after treatment, P = 0.02). Although production of IFN-g and TNF-a might be involved in the control of parasite multiplication in the early phases of Leishmania infection, these cytokines might also be involved in the tissue damage seen in tegumentary leishmaniasis.
Palavras-chave: Leishmaniose
Citocinas
Leishmaniose visceral
Imunologia
ISSN: 1414-431X
Instituição/Editora: Brazilian Journal of Medical and Biological Research
Citação: JESUS, A. M. R. et al. Cytokine profile and pathology in human leishmaniasis. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 31, n. 1, jan. 1998. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100020>. Acesso em: 20 fev. 2014.
Licença: Creative Commons Attribution License
URI: https://ri.ufs.br/handle/riufs/924
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