Use este identificador para citar ou linkar para este item: https://ri.ufs.br/jspui/handle/riufs/927
Tipo de Documento: Artigo
Título: Cytokine profile associated with human chronic schistosomiasis mansoni
Autor(es): Magalhães, Andréa
Miranda, Delfin Gonzalez
Miranda, Roberval Gonzalez
Araújo, Maria Ilma
Jesus, Adriana Almeida de
Silva, Ângela Maria da
Santana, Luciana Barros de
Pearce, Edward
Jesus, Amélia Maria Ribeiro de
Data do documento: Ago-2004
Abstract: This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-g, tumor necrosis factor-a and transforming growth factors-b) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni.
Palavras-chave: Esquistossomo
Esquistossomose
Schistosoma mansoni
Citocinas
Interleucina
Interleucina 5
Interleucina 13
ISSN: 0074-0276
Instituição/Editora: Fundação Oswaldo Cruz
Citação: MAGALHAES, A. et al. Cytokine profile associated with human chronic schistosomiasis mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, supl. 1, ago. 2004. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000900004&lng=en&nrm=iso&tlng=en>. Acesso em: 20 fev. 2014.
Licença: Creative Commons Attribution License
URI: https://ri.ufs.br/handle/riufs/927
Aparece nas coleções:DME - Artigos de periódicos

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