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Document Type: Artigo
Title: Cytokine profile associated with human chronic schistosomiasis mansoni
Authors: Magalhães, Andréa
Miranda, Delfin Gonzalez
Miranda, Roberval Gonzalez
Araújo, Maria Ilma
Jesus, Adriana Almeida de
Silva, Ângela Maria da
Santana, Luciana Barros de
Pearce, Edward
Jesus, Amélia Maria Ribeiro de
Issue Date: Aug-2004
Abstract: This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-g, tumor necrosis factor-a and transforming growth factors-b) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni.
Keywords: Esquistossomo
Schistosoma mansoni
Interleucina 5
Interleucina 13
ISSN: 0074-0276
Publisher / Institution : Fundação Oswaldo Cruz
Citation: MAGALHAES, A. et al. Cytokine profile associated with human chronic schistosomiasis mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, supl. 1, ago. 2004. Disponível em: <>. Acesso em: 20 fev. 2014.
License: Creative Commons Attribution License
Appears in Collections:DME - Artigos publicados em periódicos

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