Evolução da sobrevida de crianças e adolescentes com leucemia linfoblástica aguda em Sergipe-Brasil de 1980 a 2014

Abstract

Objectives: To evaluate the survival of children aged zero to 19 years diagnosed with acute lymphoblastic leukemia (ALL) in the period from 1980 to 2014 in the state of Sergipe. Methods: We used two databases previously existing data, in which four patients were included in two hospitals - Hospital Emergency Sergipe and Charitable Foundation Hospital Surgery - the state of Sergipe, with the diagnosis of ALL and children aged zero to 19 years from 1980 to 2014. Statistical analysis was performed using the Epi info program and survival was assessed using the Kaplan-Meier method, using SPSS version 22.0. Results: 376 children and adolescents with ALL were enrolled between 1980 and 2014. The estimated overall survival at five years was 45%. The survival rates increased progressively from 18.5% in the period 1980-1989, to 40% in 1990-1999, to 56% in 2000-2009 and 58% 2010-2014. Male gender, children between one and nine years and the low-risk group for relapse showed better survival rates. Conclusion: The outcome of ALL in the state of Sergipe, as the age group and risk of relapse were lower compared with the literature, and in terms of gender, was different from the literature presenting the female survival was significantly lower than the male. Overall survival was less than developed countries. However, over the years of the study, there was a trend of improvement in survival rates.