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https://ri.ufs.br/jspui/handle/riufs/26123| Tipo de Documento: | Artigo |
| Título: | Commentary: adenosine A2A receptor blockade prevents rotenone-induced motor impairment in a rat model of parkinsonism |
| Autor(es): | Souza, Marina Freire de Bispo, José Marcos Meneses Leal, Pollyana Caldeira Gois, Auderlan Mendonça de Santos, José Ronaldo dos |
| Data do documento: | 2017 |
| Resumo: | A recently published paper by Fathalla et al. (2016), demonstrated a rotenone induced possible protective effect of ZM241385 (a selective A2A receptor antagonist), but not of 8-cyclopentyl-1,3- dipropylxanthine (a selective A1 receptor antagonist), in a rat model of Parkinson’s disease (PD). In the present paper, the discussion is short and presents few details. This commentary aimed to emphasize certain fundamental issues involving the rotenone model, the neuroprotective capacity of A2A receptor antagonists and compensatory mechanism of the non-dopaminergic approach for the treatment of PD. Rotenone is the most potent member of the Rotenoids, a family of a natural flavonoids obtained from roots of tropical and subtropical plants belonging to the genus Lonchocarpus and Derris (Alam and Schmidt, 2002). Despite some limitations regarding variability and reproducibility seen in the animal model of PD induced by rotenone (Cannon et al., 2009), this model seems to replicate many hallmarks of illness including α-synuclein aggregation and Lewy body formation (Martinez and Greenamyre, 2012). Rotenone has lipophilic nature, and this feature induces nigrostriatal degeneration because rotenone inhibits complex I of the mitochondrial electron transport chain, decreasing ATP production, which can form reactive oxygen species such as superoxide, and reduced glutathione levels cause oxidative stress and cell death (Duty and Jenner, 2011; Johnson and Bobrovskaya, 2015). Fathalla et al. (2016) showed a progressive model of PD induced by six subcutaneous injections of rotenone. In this model, animals exhibited motor deficits as well as reduced level of dopamine in the midbrain. |
| Palavras-chave: | Parkinson disease Adenosine Neuroprotection Caffeine Dopamine |
| ISSN: | 1662-5153 |
| Parte de : | Frontiers in Behavioral Neuroscience |
| Idioma: | eng |
| Instituição/Editora: | Frontiers Media S. A. |
| Citação: | SOUZA, M. F. et al. Commentary: adenosine A2A receptor blockade prevents rotenone-induced motor impairment in a rat model of parkinsonism. Frontiers in Behavioral Neuroscience, Lausanne, v. 11, n. 93, 2017. DOI: https://doi.org/10.3389/fnbeh.2017.00093. Disponível em: https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2017.00093/full. Acesso em: 16 set. 2026. |
| Licença: | Creative Commons Atribuição 4.0 Internacional (CC BY 4.0) |
| Identificador: | https://doi.org/10.3389/fnbeh.2017.00093 |
| URI: | https://ri.ufs.br/jspui/handle/riufs/26123 |
| Aparece nas coleções: | DBCI - Artigos de periódicos |
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| AdenosineReceptorBlockadePreventsRotenoteInducedMotorImpairment.pdf | 1,56 MB | Adobe PDF |  Visualizar/Abrir |
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