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https://ri.ufs.br/jspui/handle/riufs/1212
Tipo de Documento: | Artigo |
Título: | Evaluation of the anti-Inflammatory and antinociceptive effects of the essential oil from leaves of Xylopia laevigata in experimental models |
Autor(es): | Antoniolli, Ângelo Roberto Queiroz, João Carlos C. Quintans-Júnior, Lucindo José Brito, Renan Guedes de Barreto, Rosana de Souza Siqueira Costa, Emmanoel Vilaça Silva, Thanany Brasil da Prata, Ana Paula do Nascimento Lucca Júnior, Waldecy de Almeida, Jackson Roberto Guedes da Silva Lima, Julianeli Tolentino de Quintans, Jullyana de Souza Siqueira |
Data do documento: | 3-Jul-2014 |
Abstract: | Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of y-muurolene (17.78%), o-cadinene (12.23%), bicyclogermacrene (7.77%), and a-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (p < 0.05 or p < 0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (p < 0.01 or p < 0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders. |
Palavras-chave: | Xylopia laevigata (Annonaceae) Atividade antinociceptiva Anti-inflamatório |
Instituição/Editora: | Hindawi Publishing Corporation |
Citação: | QUEIROZ, J. C. C. et. al. Evaluation of the anti-Inflammatory and antinociceptive effects of the essential oil from leaves of Xylopia laevigata in experimental models. The Scientific World Journal, v. 2014, jul. 2014. Disponível em: <s http://dx.doi.org/10.1155/2014/816450>. Acesso em: 17 set. 2014. |
Licença: | Creative Commons Attribution License |
URI: | https://ri.ufs.br/handle/riufs/1212 |
Aparece nas coleções: | DBI - Artigos de periódicos DFS - Artigos de periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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EvaluationOfThe.pdf | 3,79 MB | Adobe PDF | ![]() Visualizar/Abrir |
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