Please use this identifier to cite or link to this item: http://ri.ufs.br/jspui/handle/riufs/1212
Document Type: Artigo
Title: Evaluation of the anti-Inflammatory and antinociceptive effects of the essential oil from leaves of Xylopia laevigata in experimental models
Authors: Antoniolli, Ângelo Roberto
Queiroz, João Carlos C.
Quintans-Júnior, Lucindo José
Brito, Renan Guedes de
Barreto, Rosana de Souza Siqueira
Costa, Emmanoel Vilaça
Silva, Thanany Brasil da
Prata, Ana Paula do Nascimento
Lucca Júnior, Waldecy de
Almeida, Jackson Roberto Guedes da Silva
Lima, Julianeli Tolentino de
Quintans, Jullyana de Souza Siqueira
Issue Date: 3-Jul-2014
Abstract: Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of y-muurolene (17.78%), o-cadinene (12.23%), bicyclogermacrene (7.77%), and a-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (p < 0.05 or p < 0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (p < 0.01 or p < 0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders.
Keywords: Xylopia laevigata (Annonaceae)
Atividade antinociceptiva
Anti-inflamatório
Publisher / Institution : Hindawi Publishing Corporation
Citation: QUEIROZ, J. C. C. et. al. Evaluation of the anti-Inflammatory and antinociceptive effects of the essential oil from leaves of Xylopia laevigata in experimental models. The Scientific World Journal, v. 2014, jul. 2014. Disponível em: <s http://dx.doi.org/10.1155/2014/816450>. Acesso em: 17 set. 2014.
License: Creative Commons Attribution License
URI: https://ri.ufs.br/handle/riufs/1212
Appears in Collections:DBI - Artigos publicados em periódicos
DFS - Artigos publicados em periódicos

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