1. Repositório Institucional da Universidade Federal de Sergipe - RI/UFS
2. PRODUÇÃO CIENTÍFICA
3. DFS - Departamento de Fisiologia
4. DFS - Artigos de periódicos

Tipo de Documento:	Artigo
Título :	Lycopene and ß-carotene protect in vivo iron-induced oxidative stress damage in rat prostate
Autor :	Matos, Humberto Reis Marques, Sabrina de Almeida Gomes, Osmar Francisco Silva, Alexandre Alves da Heimann, Joel Claudio Di Mascio, Paolo Medeiros, Marisa Helena Gennari de
Fecha de publicación :	2006
Resumen:	It has been suggested that iron overload may be carcinogenic. In the present study, we evaluated the effect of plasma and prostate carotenoid concentration on oxidative DNA damage in 12-week-old Wistar rats treated with intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) (10 mg Fe/kg). Plasma ß-carotene and lycopene concentrations were measured as a function of time after ip injection of carotenoids (10 mg kg-1 day-1 ß-carotene or lycopene) in rats. The highest total plasma concentration was reached 3 and 6 h after ip injection of lycopene or ß-carotene, respectively. After 5 days of carotenoid treatment, lycopene and ß-carotene were present in the 0.10-0.51 nmol/g wet tissue range in the prostate. Using a sensitive method to detected 8-oxo-7,8- dihydro-2'-deoxyguanosine (8-oxodGuo) by HPLC/EC, the level of 8-oxodGuo in rat prostate DNA was significantly higher (6.3 ± 0.6 residues/106 dGuo) 3 h after Fe-NTA injection compared with control rats (1.7 ± 0.3 residues/106 dGuo). Rats supplemented with lycopene or ß-carotene for 5 days prior to Fe-NTA treatment showed a reduction of about 70% in 8-oxodGuo levels to almost control levels. Compared with control rats, the prostate of Fe-NTA-treated animals showed a 78% increase in malondialdehyde accumulation. Lycopene or ßcarotene pre-treatment almost completely prevented lipid damage. Epidemiological studies have suggested a lower risk of prostate cancer in men reporting a higher consumption of tomato products. However, before associating this effect with tomato sauce constituents, more information is required. The results described here may contribute to the understanding of the protective effects of carotenoids against iron-induced oxidative stress.
Palabras clave :	Lycopene ß-carotene DNA damage 8-oxo-7,8-dihydro-2'-deoxyguanosine Ferric nitrilotriacetate Prostate cancer Câncer de próstata Licopeno Betacaroteno
ISSN :	0100-879X 1414-431X
Es parte de:	Brazilian Journal of Medical and Biological Research
Idioma :	eng
Institución / Editorial :	Associação Brasileira de Divulgação Científica
Citación :	MATOS, H. R. et al. Lycopene and ß-carotene protect in vivo iron-induced oxidative stress damage in rat prostate. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 39, n. 2, p. 203-210, fev. 2006. Disponível em: https://www.scielo.br/j/bjmbr/a/BmxwSZZKKww44krKsdJLjKH/?format=pdf&lang=en. Acesso em: 19 nov. 2024.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
URI :	https://ri.ufs.br/jspui/handle/riufs/20472
Aparece en las colecciones:	DFS - Artigos de periódicos

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.