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https://ri.ufs.br/jspui/handle/riufs/21372Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Arguelho, Maria de Lara Palmeira de Macedo | - |
| dc.contributor.author | Alves, José do Patrocínio Hora | - |
| dc.contributor.author | Stradiotto, Nelson Ramos | - |
| dc.contributor.author | Lacerda Júnior, Valdemar | - |
| dc.contributor.author | Pires, José Maria | - |
| dc.contributor.author | Beatriz, Adilson | - |
| dc.date.accessioned | 2025-03-14T13:05:37Z | - |
| dc.date.available | 2025-03-14T13:05:37Z | - |
| dc.date.issued | 2010 | - |
| dc.identifier.citation | ARGUELHO, M. L. P. M. et al. Electrochemical and theoretical evaluation of the interaction between DNA and amodiaquine: evidence of the guanine adduct formation. Química Nova, São Paulo, v. 33, n. 6, p. 1291-1296, 2010. Disponível em: https://www.scielo.br/j/qn/a/7VcfZzJtBJjzGrTSfCfbBFB/?format=pdf&lang=en. Acesso em: 14 mar. 2025. | pt_BR |
| dc.identifier.issn | 0100-4042 | - |
| dc.identifier.issn | 1678-7064 | - |
| dc.identifier.uri | https://ri.ufs.br/jspui/handle/riufs/21372 | - |
| dc.language | eng | pt_BR |
| dc.publisher | Sociedade Brasileira de Química | pt_BR |
| dc.relation.ispartof | Química Nova | pt_BR |
| dc.subject | Amodiaquine | eng |
| dc.subject | Guanine | eng |
| dc.subject | Adduct | eng |
| dc.title | Electrochemical and theoretical evaluation of the interaction between DNA and amodiaquine: evidence of the guanine adduct formation | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.identifier.license | Creative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0) | pt_BR |
| dc.description.resumo | The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA. | pt_BR |
| dc.description.local | São Paulo, SP | pt_BR |
| Aparece en las colecciones: | DQI - Artigos de periódicos | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| ElectrochemicalInteractionDNAAmodiaquine.pdf | 716,31 kB | Adobe PDF |  Visualizar/Abrir |
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