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Please use this identifier to cite or link to this item: https://ri.ufs.br/jspui/handle/riufs/21372
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dc.contributor.authorArguelho, Maria de Lara Palmeira de Macedo-
dc.contributor.authorAlves, José do Patrocínio Hora-
dc.contributor.authorStradiotto, Nelson Ramos-
dc.contributor.authorLacerda Júnior, Valdemar-
dc.contributor.authorPires, José Maria-
dc.contributor.authorBeatriz, Adilson-
dc.date.accessioned2025-03-14T13:05:37Z-
dc.date.available2025-03-14T13:05:37Z-
dc.date.issued2010-
dc.identifier.citationARGUELHO, M. L. P. M. et al. Electrochemical and theoretical evaluation of the interaction between DNA and amodiaquine: evidence of the guanine adduct formation. Química Nova, São Paulo, v. 33, n. 6, p. 1291-1296, 2010. Disponível em: https://www.scielo.br/j/qn/a/7VcfZzJtBJjzGrTSfCfbBFB/?format=pdf&lang=en. Acesso em: 14 mar. 2025.pt_BR
dc.identifier.issn0100-4042-
dc.identifier.issn1678-7064-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/21372-
dc.languageengpt_BR
dc.publisherSociedade Brasileira de Químicapt_BR
dc.relation.ispartofQuímica Novapt_BR
dc.subjectAmodiaquineeng
dc.subjectGuanineeng
dc.subjectAdducteng
dc.titleElectrochemical and theoretical evaluation of the interaction between DNA and amodiaquine: evidence of the guanine adduct formationpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0)pt_BR
dc.description.resumoThe electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.pt_BR
dc.description.localSão Paulo, SPpt_BR
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