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Document Type:	Artigo
Title:	Differential cortical c-Fos and Zif-268 expression after object and spatial memory processing in a standard or episodic-like object recognition task
Authors:	Barbosa, Flávio Freitas Santos, José Ronaldo Meurer, Ywlliane da Silva Rodrigues Macêdo, Priscila Tavares Ferreira, Luane Maria Stamatto Fernandes, Isabella Maria de Oliveira Pontes Ribeiro, Alessandra Mussi Silva, Regina Helena
Issue Date:	Aug-2013
Resumo :	Episodic memory reflects the capacity to recollect what, where, and when a specific event happened in an integrative manner. Animal studies have suggested that the medial temporal lobe and the medial pre-frontal cortex are important for episodic-like memory (ELM) formation.The goal of present study was to evaluate whether there are different patterns of expression of the immediate early genes c-Fos and Zif-268 in these cortical areas after rats are exposed to object recognition (OR) tasks with different cognitive demands. Male rats were randomly assigned to five groups: home cage control, empty open field (CTR-OF), open field with one object (CTR-OF + Obj), novel OR task, and ELM task and were killed 1 h after the last behavioral procedure. Rats were able to discriminate the objects in the OR task. In the ELM task, rats showed spatial (but not temporal) discrimination of the objects. We found an increase in the c-Fos expression in the dorsal dentate gyrus (DG) and in the perirhinal cortex (PRh) in the OR and ELM groups.The OR group also presented an increase of c-Fos expression in the medial prefrontal cortex (mPFC). Additionally, the OR and ELM groups had increased expression of Zif-268 in the mPFC. Moreover, Zif-268 was increased in the dorsal CA1 and PRh only in the ELM group. In conclusion, the pattern of activation was different in tasks with different cognitive demands. Accordingly, correlation tests suggest the engagement of different neural networks in the tasks used. Specifically, perirhinal-DG co-activation was detected after the what-where memory retrieval, but not after the novel OR task. Both regions correlated with the respective behavioral outcome. These findings can be helpful in the understanding of the neural networks underlying memory tasks with different cognitive demands.
Keywords:	Recognition memory Spatial memory Episodic memory Immediate early genes Plasticity Hippocampus
ISSN:	1662-5153
Is part of:	Frontiers in Behavioral Neuroscience
Language:	eng
Publisher / Institution :	Frontiers Media S. A.
Citation:	BARBOSA, F. F. et al. Differential cortical c-Fos and Zif-268 expression after object and spatial memory processing in a standard or episodic-like object recognition task. Frontiers in Behavioral Neuroscience, Lausanne, v. 7, n. 112, ago. 2013. Disponível em: https://www.frontiersin.org/journals/behavioral-neuroscience/articles/10.3389/fnbeh.2013.00112/full. Acesso em: 21 out. 2025.
License:	Creative Commons Atribuição-NãoComercial 3.0 Não Adaptada (CC BY-NC 3.0)
URI:	https://ri.ufs.br/jspui/handle/riufs/23591
Appears in Collections:	DBI - Artigos de periódicos

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