Distinct morphological features of NADPH diaphorase neurons across rodent's primary cortices

Freire, Marco Aurelio de Moura; Santos, José Ronaldo dos

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Campo DC	Valor	Idioma
dc.contributor.author	Freire, Marco Aurelio de Moura	-
dc.contributor.author	Santos, José Ronaldo dos	-
dc.date.accessioned	2025-11-04T20:37:21Z	-
dc.date.available	2025-11-04T20:37:21Z	-
dc.date.issued	2013-04	-
dc.identifier.citation	FREIRE, M. A. M.; SANTOS, J. R. Distinct morphological features of NADPH diaphorase neurons across rodent's primary cortices. Frontiers in Neural Circuits, Lausanne, v. 7, n. 83, abr. 2013. Disponível em: https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2013.00083/full. Acesso em: 4 nov. 2025.	pt_BR
dc.identifier.issn	1662-5110	-
dc.identifier.uri	https://ri.ufs.br/jspui/handle/riufs/23737	-
dc.language	eng	pt_BR
dc.publisher	Frontiers Media S. A.	pt_BR
dc.relation.ispartof	Frontiers in Neural Circuits	pt_BR
dc.subject	Nitric oxide	eng
dc.subject	NADPH	eng
dc.subject	Morphological features	eng
dc.subject	Diaphorase neurons	eng
dc.title	Distinct morphological features of NADPH diaphorase neurons across rodent's primary cortices	pt_BR
dc.type	Artigo	pt_BR
dc.identifier.license	Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)	pt_BR
dc.description.resumo	Nitric oxide (NO) is a versatile gaseous molecule involved in several pathological and physiological functions in nervous system (Calabrese et al., 2007; Steinert et al., 2010; Freire, 2012). Its biosynthesis occurs after the stoichiometric conversion of L-arginine to L-citrulline in a process requiring the presence of NADPH and O2 as co-substrates (Bredt and Snyder, 1994). A group of enzymes known as nitric oxide synthases (NOS) is responsible to synthesize NO (Stuehr et al., 2004). In the brain, neuronal NOS is strictly co-localized with NADPH diaphorase (NADPH-d), an oxidative enzyme present in a discrete population of interneurons (Dawson et al., 1991). NADPH-d histochemistry has been used to reveal the presence of NO dispersed in neuropil and to evaluate the presence and distribution of NO-synthesizing neurons across several species.	pt_BR
dc.description.local	Lausanne	pt_BR
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