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Please use this identifier to cite or link to this item: https://ri.ufs.br/jspui/handle/riufs/24168
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dc.contributor.authorCalvo, Ana Cristina-
dc.contributor.authorManzano, Raquel-
dc.contributor.authorMendonça, Deise Maria Furtado de-
dc.contributor.authorMuñoz, María J.-
dc.contributor.authorZaragoza, Pilar-
dc.contributor.authorOsta, Rosario-
dc.date.accessioned2026-01-09T16:48:53Z-
dc.date.available2026-01-09T16:48:53Z-
dc.date.issued2014-08-
dc.identifier.citationCALVO, A. C. et al. Amyotrophic lateral sclerosis: a focus on disease progression. BioMed Research International, v. 2014, ago. 2014. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1155/2014/925101. Acesso em: 9 jan. 2026.pt_BR
dc.identifier.issn2314-6141-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/24168-
dc.languageengpt_BR
dc.publisherHindawi Publishing Corporationpt_BR
dc.relation.ispartofBioMed Research Internationalpt_BR
dc.subjectAmyotrophic lateral sclerosiseng
dc.subjectNeurodegenerative diseaseseng
dc.subjectDisease progressioneng
dc.subjectTherapeutic strategieseng
dc.titleAmyotrophic lateral sclerosis: a focus on disease progressionpt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)pt_BR
dc.description.resumoSince amyotrophic lateral sclerosis (ALS) was discovered and described in 1869 as a neurodegenerative disease in which motorneuron death is induced, a wide range of biomarkers have been selected to identify therapeutic targets. ALS shares altered molecular pathways with other neurodegenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s diseases. However,the molecular targets that directly influence its aggressive nature remain unknown. What is the first link in the neurodegenerativechain of ALS that makes this disease so peculiar? In this review, we will discuss the progression of the disease from the viewpointof the potential biomarkers described to date in human and animal model samples. Finally, we will consider potential therapeuticstrategies for ALS treatment and future, innovative perspectives.pt_BR
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