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Please use this identifier to cite or link to this item: https://ri.ufs.br/jspui/handle/riufs/24757
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dc.contributor.authorDória, Grace Anne Azevedo-
dc.contributor.authorSantos, Anderson Ribeiro dos-
dc.contributor.authorBittencourt, Leonardo S.-
dc.contributor.authorBortolin, Rafael Calixto-
dc.contributor.authorMenezes, Paula dos Passos-
dc.contributor.authorVasconcelos, Bruno S.-
dc.contributor.authorSouza, Rebeca O.-
dc.contributor.authorFonseca, Maria José Vieira-
dc.contributor.authorSantos, Alan Diego da Conceição-
dc.contributor.authorSaravana, Shanmugam-
dc.contributor.authorSilva, Francilene Amaral da-
dc.contributor.authorGelain, Daniel Pens-
dc.contributor.authorMoreira, José Claudio Fonseca-
dc.contributor.authorPrata, Ana Paula do Nascimento-
dc.contributor.authorQuintans Júnior, Lucindo José-
dc.contributor.authorAraújo, Adriano Antunes de Souza-
dc.date.accessioned2026-03-12T19:05:16Z-
dc.date.available2026-03-12T19:05:16Z-
dc.date.issued2015-
dc.identifier.citationDÓRIA, G. A. A. et al. Redox-active profile characterization of Remirea maritima extracts and its cytotoxic effect in mouse fibroblasts (L929) and melanoma (B16f10) cells. Molecules, Basel, v. 20, n. 7, p. 11669–11718, 2015. Disponível em: https://www.mdpi.com/1420-3049/20/7/11699. Acesso em: 12 mar. 2026.pt_BR
dc.identifier.issn1420-3049-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/24757-
dc.languageengpt_BR
dc.publisherMDPIpt_BR
dc.relation.ispartofMoleculespt_BR
dc.subjectRemirea maritimaeng
dc.subjectFree radicalseng
dc.subjectCellular viabilityeng
dc.subjectOxidative stresseng
dc.subjectCytotoxicityeng
dc.subjectTotal phenoleng
dc.titleRedox-active profile characterization of Remirea maritima extracts and its cytotoxic effect in mouse fibroblasts (L929) and melanoma (B16f10) cellspt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoRemirea maritima is a tropical plant with a reticulated root system belonging to the family Cyperaceae, also known to have biologically active secondary metabolites. However, very few data on R. maritima’s biological actions are available and there are no reports regarding the redox-active profile of this plant. In this study, we examined the total phenolic content of Remirea maritima hydroalcoholic (RMHA) extracts, redox properties against different reactive species generated in vitro and their cytotoxic effect against fibroblasts (L929) and melanoma (B16F10) cells. Total reactive antioxidant potential index (TRAP) and total antioxidant reactivity (TAR) results revealed that RMHA at all concentrations tested showed significant antioxidant capacity. RMHA was also effective against hydroxyl radical formation, reduction of Fe3+ to Fe2+ and in scavenging nitric oxide (NO) radicals. In vitro, the level of lipid peroxidation was reduced by RMHA extract and the data showed significant oxidative damage protection. The RMHA cytotoxicity was evaluated by a neutral red assay in fibroblast (L929) and melanome (B16F10) cells. The obtained results showed that the RMHA (40 and 80 µg/mL, respectively) reduced 70% of the viable cells. In conclusion, this study represents the first report regarding the antioxidant and anti-proliferative potential of R. maritima against B16F10 melanoma cells.pt_BR
dc.description.localBaselpt_BR
dc.identifier.doihttps://doi.org/10.3390/molecules200711699-
Appears in Collections:DBI - Artigos de periódicos
DFA - Artigos de periódicos
DFS - Artigos de periódicos

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