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Please use this identifier to cite or link to this item: https://ri.ufs.br/jspui/handle/riufs/25877
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dc.contributor.authorBaldim, João Luiz-
dc.contributor.authorAlcântara, Bianca Gonçalves Vasconcelos de-
dc.contributor.authorDomingos, Olívia da Silva-
dc.contributor.authorSoares, Marisi Gomes-
dc.contributor.authorCaldas, Ivo Santana-
dc.contributor.authorNovaes, Rômulo Dias-
dc.contributor.authorOliveira, Tiago Branquinho-
dc.contributor.authorLago, João Henrique Ghilardi-
dc.contributor.authorChagas-Paula, Daniela Aparecida-
dc.date.accessioned2026-08-24T20:29:40Z-
dc.date.available2026-08-24T20:29:40Z-
dc.date.issued2017-
dc.identifier.citationBALDIM, J. L. et al. The correlation between chemical structures and antioxidant, prooxidant, and antitrypanosomatid properties of flavonoids. Oxidative Medicine and Cellular Longevity, New York, n. 1, 2017. DOI: https://doi.org/10.1155/2017/3789856. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2017/3789856. Acesso em: 24 ago. 2026.pt_BR
dc.identifier.issn1942-0994-
dc.identifier.urihttps://ri.ufs.br/jspui/handle/riufs/25877-
dc.languageengpt_BR
dc.publisherHindawi Publishing Corporationpt_BR
dc.relation.ispartofOxidative Medicine and Cellular Longevitypt_BR
dc.subjectFlavonoidseng
dc.subjectChemical structureseng
dc.subjectDrug resistanceeng
dc.subjectProoxidant activitieseng
dc.subjectAntioxidant activitieseng
dc.titleThe correlation between chemical structures and antioxidant, prooxidant, and antitrypanosomatid properties of flavonoidspt_BR
dc.typeArtigopt_BR
dc.identifier.licenseCreative Commons Atribuição 4.0 Internacional (CC BY 4.0)pt_BR
dc.description.resumoFlavonoids have demonstrated in vivo and in vitro leishmanicidal, trypanocidal, antioxidant, and prooxidant properties. Thechemotherapy of trypanosomiasis and leishmaniasis lacks efficacy, presents high toxicity, and is related to the development ofdrug resistance. Thus, a series of 40 flavonoids were investigated with the purpose of correlating these properties via structureand activity analyses based on integrated networks and QSAR models. The classical groups for the antioxidant activity offlavonoids were combined in order to explain the influence of antioxidant and prooxidant activities on the antiparasiticproperties. These analyses become useful for the development of efficient treatments for leishmaniasis and trypanosomiasis.Finally, the dual activity of flavonoids presenting both anti- and prooxidant activities revealed that the existence of a balancebetween these two features could be important to the development of adequate therapeutic strategies.pt_BR
dc.description.localNew Yorkpt_BR
dc.identifier.doihttps://doi.org/10.1155%2F2017%2F3789856-
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