Please use this identifier to cite or link to this item:
https://ri.ufs.br/jspui/handle/riufs/589
Document Type: | Artigo |
Title: | Bioassay-guided evaluation of central nervous system effects of citronellal in rodents |
Authors: | Melo, Mônica Santos de Souza, Marilia Trindade de Santana Guimarães, Adriana Gibara Barreto, Rosana de Souza Siqueira Barreto, Rosana de Souza Siqueira Quintans-Júnior, Lucindo José Santos, Márcio Roberto Viana dos Bonjardim, Leonardo Rigoldi Araújo, Adriano Antunes de Souza Onofre, Alexandre Sherlley Casimiro Lima, Julianeli Tolentino de Almeida, Jackson Roberto Guedes da Silva |
Issue Date: | Aug-2011 |
Abstract: | The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaining time of the animals on the Rota-rod apparatus up to 2 h. Additionally, CT at doses 100, 200 and 400 mg/ kg (i.p.) was also capable to promote an increase of latency for development of convulsions induced by pentylenetetrazole (PTZ). It was efficient in prevents the tonic convulsions induced by maximal electroshock (MES) in doses of 200 and 400 mg/kg, resulting in 30 and 40% of protection, respectively. This compound was also capable to promote an increase of latency for development of convulsions induced by picrotoxin (PIC) at 400 mg/kg. In the same way, the anticonvulsant effect of CT was affected by pretreatment with flumazenil, a selective antagonist of benzodiazepine site of GABAA receptor. These results suggest a possible CNS depressant and anticonvulsant activities. |
Keywords: | Atividade anticonvulsivante Citronela Monoterpenos Atividade depressora |
ISSN: | 0102-695X |
Citation: | MELO, M. S. et al. Bioassay-guided evaluation of central nervous system effects of citronellal in rodents. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 4, Ago. 2011. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000400020&lng=en&nrm=iso>. Acesso em: 7 jun. 2013. |
License: | Creative Commons Attribution License |
URI: | https://ri.ufs.br/handle/riufs/589 |
Appears in Collections: | DESL - Artigos de periódicos DFA - Artigos de periódicos |
Files in This Item:
File | Description | Size | Format | |
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BioassayCentralNervous.pdf | 749,77 kB | Adobe PDF | ![]() View/Open |
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